Current Controversies in Clinical Management of Postmenopausal Osteoporosis

K. Kerschan-Schindl; P. Mikosch; B. Obermayer-Pietsch; R. W. Gasser; H.-P. Dimai; A. Fahrleitner-Pammer; H. Dobnig; P. Roschger; E. Preisinger; K. Klaushofer; H. Resch; P. Pietschmann

doi:10.1055/s-0034-1374610

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2014; 122(08): 437-444
DOI: 10.1055/s-0034-1374610

Review

Current Controversies in Clinical Management of Postmenopausal Osteoporosis

K. Kerschan-Schindl

¹Department of Physical Medicine & Rehabilitation, Medical University of Vienna

,

P. Mikosch

²1st Medical Department and Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Vienna

,

B. Obermayer-Pietsch

³Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz

,

R. W. Gasser

⁴Department of Internal Medicine I, Medical University of Innsbruck

,

H.-P. Dimai

³Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz

,

A. Fahrleitner-Pammer

³Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz

,

H. Dobnig

⁵Schilddrüsen Endokrinologie Osteoporose Institut Dobnig GmbH, Graz

,

P. Roschger

²1st Medical Department and Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Vienna

,

E. Preisinger

⁶Institute for Physical Medicine and Rehabilitation, Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel, Vienna

,

K. Klaushofer

²1st Medical Department and Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Vienna

,

H. Resch

⁷Department II Rheumatology/Osteology & Gastroenterology, St Vincent Hospital, Vienna

,

P. Pietschmann

⁸Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna

› Author Affiliations

Abstract

Osteoporosis is a frequent disease in postmenopausal women. Despite the fact that fragility fractures cause many problems – a bio-psycho-social burden for the individual and an economic burden for the society – osteoporosis is still underdiagnosed and undertreated. Controversies exist concerning assessment with different tools for initiating a disease-specific treatment, patient monitoring with bone turnover markers, and treatment duration due to potential side effects in long-term treatment. This manuscript outlines and discusses these controversies and the presented cases, representatives for frequent clinical problems, may give guidance for the clinician in deciding how and how long to treat his/her patient. Re-evaluations of the patients on a regular basis are essential to warrant the necessity of treatment continuation and may improve patients’ compliance.

Key words

postmenopausal osteoporosis - bisphosphonate - long-term treatment - biomarkers - bone mineral density - bone mineralization density distribution

Full Text

References

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