The over-the-scope clip (OTSC) system was developed for the closure of perforations
and fistulas, and for the endoscopic therapy of gastrointestinal bleeding. Small mucosal
and submucosal neoplastic lesions can be aspirated into the cap and, after releasing
the clip, a “pseudopolyp” is created. This pseudopolyp located above the closed clip
can then be resected using a polypectomy snare. However, placing a snare on the pseudopolyp
may be difficult due to the shape of the clip. Herein, we present a dual technique
using both the OTSC and the Inoue cap to accomplish endoscopic full-thickness resection
(eFTR).
An 80-year-old patient who had undergone incomplete endoscopic resection (R1) of a
15-mm sigmoid colon polyp with carcinoma (SM1), underwent an eFTR of the remaining
base of the lesion using this new technique. The procedure was performed 14 days after
initial polypectomy. The steps of the technique were as follows. 1) The tissue was
pulled into the cap of the OTSC system (14/6 t; Ovesco Endoscopy AG, Tübingen, Germany)
using a grasping forceps to create a pseudopolyp. An important aspect of this technique
is to avoid fitting too much of the cap over the distal end of the endoscope, as it
is important to ensure that there is sufficient cap volume for the entrapment of tissue.
2) The OTSC was then released at the base of the pseudopolyp, thus securing the bowel
wall. 3) The scope was removed, and the Inoue endoscopic mucosal resection (EMR) cap
(Olympus, Hamburg, Germany) was loaded onto the endoscope. 4) The Inoue cap loaded
with the snare was then directed onto the pseudopolyp and a resection was performed
above the OTSC ([Fig. 1]). Of note, this part of the procedure is not a simple EMR, as the resulting resection
often results in FTR. An additional advantage of this technique is that the distal
web of the Inoue cap may function as electric insulation, thus preventing the contact
of the resection snare with the exposed metallic clip.
Fig. 1 Use of the Dortmund endoscopic full-thickness resection method, combining the over-the-scope
clip (OTSC) system and the Inoue cap, following incomplete endoscopic resection of
a sigmoid colon polyp. a The tissue is pulled into the cap of the OTSC. b The OTSC is released at the base of the pseudopolyp. c The Inoue endoscopic mucosal resection kit (cap with snare) suctioning the pseudopolyp
above the clip. d The bowel base after resection.
The size of the resection specimen was 25 mm. Histological analysis did not reveal
any carcinoma in the lateral or vertical margins of the lesion. The patient recovered
well and surgery was thus avoided.
Endoscopy_UCTN_Code_CPL_1AJ_2AD
