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Synthesis 2014; 46(14): 1847-1852
DOI: 10.1055/s-0034-1378350
DOI: 10.1055/s-0034-1378350
practical synthetic procedures
A Convenient Practical Synthesis of Alkyl and Aryl Oxime Esters
Further Information
Publication History
Received: 03 February 2014
Accepted after revision: 30 May 2014
Publication Date:
24 June 2014 (online)
Abstract
A facile access to the synthesis of alkyl and aryl oxime esters of ketoximes and aldoximes in high yields (90–97%) is reported. The reactions were performed using N-[3-(methylamino)propyl]-N′-ethylcarbodiimide hydrochloride (EDCI) reagent in the presence of 4-(dimethylamino)pyridine (DMAP) as a catalyst at room temperature. The isolation and purification of products is very simple and in cases where product is solid, column chromatography is avoided.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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