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Synlett 2014; 25(14): 2072-2074
DOI: 10.1055/s-0034-1378496
DOI: 10.1055/s-0034-1378496
letter
Proline-Catalyzed Dehydrogenative Cross-Coupling Reaction between Chromene and Aldehydes
Further Information
Publication History
Received: 30 April 2014
Accepted after revision: 14 June 2014
Publication Date:
16 July 2014 (online)
![](https://www.thieme-connect.de/media/synlett/201414/lookinside/thumbnails/10.1055-s-0034-1378496-1.jpg)
Abstract
An unprecedented DCC reaction between chromene and aldehydes catalyzed by proline has been developed via direct C–H functionalization. A plausible mechanism using DDQ to activate α-C–H of chromene and proline to activate aldehyde is also proposed.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
- Supporting Information
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References and Notes
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For reviews on DCC reactions, see:
Ethers were oxidized by DDQ to form oxocarbenium ions. For details, see: