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DOI: 10.1055/s-0034-1378706
Enamide Derivatives: Versatile Building Blocks for Total Synthesis
Publication History
Received: 30 January 2015
Accepted after revision: 16 March 2015
Publication Date:
27 May 2015 (online)
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Abstract
Enamides and enecarbamates are versatile building blocks in organic synthesis. This review describes the development of enamide chemistry and the utility of the resulting products in the synthesis of a variety of important, biologically active molecules.
1 Introduction
2 Asymmetric Hydrogenation of Enamides
3 Monofunctionalization of Enamide Derivatives
3.1 Palladium-Catalyzed α-Functionalization of Enamide Derivatives
3.2 Ruthenium-Catalyzed β-Functionalization of Enamide Derivatives
4 Ionic Vicinal Difunctionalization of Enamide Derivatives
4.1 Tandem Difunctionalization of Enamide Derivatives
4.2 Cycloadditions
4.2.1 [4+2] Cycloadditions
4.2.2 [2+2] Cycloadditions
4.2.3 Cyclopropanation of Enamides
4.3 Other Pericyclic Reactions
4.3.1 Electrocyclization Reactions
4.3.2 Overman Rearrangement
4.4 Platinum-Catalyzed Vicinal Difunctionalization of Enamide Derivatives
5 Radical Vicinal Difunctionalization of Enamide Derivatives
6 Oxidative Vicinal Difunctionalization of Enamide Derivatives
7 N-Arylation of Enecarbamates
8 Conclusion
9 Ligand Glossary
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Also see:
For a review on electrophilic and nucleophilic substitution and addition reactions of enamines, see:
For a review covering asymmetric organocatalysis, see:
For selected reviews on enamine catalysis, see:
Selected examples, see:
For reviews see:
For reviews on RCM in total synthesis see:
For a review see:
For reviews, see: