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Synthesis 2015; 47(20): 3241-3245
DOI: 10.1055/s-0034-1378747
DOI: 10.1055/s-0034-1378747
paper
A Convenient Synthesis of 2-Fluoro- and 2-Chloromalonic Esters Mediated by Hypervalent Iodine
Further Information
Publication History
Received: 26 May 2015
Accepted after revision: 29 June 2015
Publication Date:
12 August 2015 (online)
Abstract
Direct fluorination of malonic esters with a reagent system of iodosylbenzene and Et3N·5HF gave the corresponding 2-fluoromalonic esters in good to high yields. Direct chlorination using iodosylbenzene and hydrochloric acid also provided the 2-chloromalonates in high yields.
Key words
2-fluoromalonic esters - 2-chloromalonic esters - hydrogen fluoride - hydrochloric acid - iodosylbenzeneSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1378747.
- Supporting Information
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