Indium(III)-Catalyzed Reduction of Nitrobenzenes to Anilines: Scope and Limitations

Abstract

We have demonstrated that a combination of indium(III) iodide and 1,1,3,3-tetramethyldisiloxane (TMDS) effectively catalyzes the chemoselective reduction of nitrobenzenes with a variety of functional groups (halogens, alkyl, alkoxy, hydroxy, ester, amino, amide, cyanide, thiol, and an alkene moiety), producing the corresponding aniline derivatives.

Key words

indium - reduction - hydrosiloxanes - nitrobenzenes - anilines

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