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Synlett 2014; 25(16): 2370-2374
DOI: 10.1055/s-0034-1378895
DOI: 10.1055/s-0034-1378895
letter
A Novel Efficient Route for Acid-Catalyzed Synthesis of α,β-Alkynyl/Alkenyl Ketones
Further Information
Publication History
Received: 06 May 2014
Accepted after revision: 11 July 2014
Publication Date:
13 August 2014 (online)
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Abstract
Herein, we have developed a simple and efficient synthesis of α,β-alkynyl/alkenyl ketone derivatives by acid-catalyzed reactions of 2,6-dimethyl-N-(4-methylbenzylidene)aniline and alkynes. This methodology provides a novel pathway for the synthesis of α,β-alkynyl/alkenyl ketones via acid-catalyzed coupling reactions and subsequent silica gel catalyzed hydrolysis. Characterized by wide substrate scope, mild reaction conditions, and good to excellent yields this protocol may aid the further development of the C–C coupling reactions.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
- Supporting Information
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