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Synthesis 2015; 47(04): 517-525
DOI: 10.1055/s-0034-1378909
DOI: 10.1055/s-0034-1378909
paper
A Simple and Efficient Synthesis of 3,4,5-Trisubstituted/N-Fused 1,2,4-Triazoles via Ceric Ammonium Nitrate Catalyzed Oxidative Cyclization of Amidrazones with Aldehydes Using Polyethylene Glycol as a Recyclable Reaction Medium
Further Information
Publication History
Received: 23 July 2014
Accepted after revision: 06 October 2014
Publication Date:
20 November 2014 (online)
Abstract
An environmentally benign protocol is described for the synthesis of 3,4,5-trisubstituted 1,2,4-triazoles and N-fused 1,2,4-triazoles via ceric ammonium nitrate catalyzed oxidative cyclization of amidrazones and aldehydes using polyethylene glycol as recyclable reaction medium. This protocol is effective toward various substrates having different functionalities. The easy recyclability of the reaction medium makes the process economic and potentially viable for commercial applications.
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