Mild Benzylic Monobromination of Methyl Toluates in Aqueous CTAB

Abstract

A strategy has been developed for the regioselective monobromination of methyl toluates by using tert-butylhydrogen peroxide and potassium bromide (TBHP/KBr) in a cetyltrimethylammonium bromide (CTAB) micellar medium. Ultrasonic and microwave-assisted protocols recorded increased rates and product yields under mild reaction conditions, coupled with a straightforward isolation procedure.

Key words

bromination - monobromo methyl toluates - cetyltrimethylammonium bromide - microwaves - ultrasound

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