A Rapid One-Pot Ugi Reaction Based Route to Novel Imidazole-Fused Benzodiazepinones

Debleena Bhattacharya; Sudipta Mitra; Partha Chattopadhyay

doi:10.1055/s-0034-1379916

Synthesis, Table of Contents

Synthesis 2015; 47(15): 2294-2298
DOI: 10.1055/s-0034-1379916

paper

A Rapid One-Pot Ugi Reaction Based Route to Novel Imidazole-Fused Benzodiazepinones

Debleena Bhattacharya

CSIR – Indian Institute of Chemical Biology, Department of Chemistry, 4 Raja S. C. Mullick Road, Kolkata 700 032, India Email: partha@iicb.res.in

,

Sudipta Mitra

CSIR – Indian Institute of Chemical Biology, Department of Chemistry, 4 Raja S. C. Mullick Road, Kolkata 700 032, India Email: partha@iicb.res.in

,

Partha Chattopadhyay*

CSIR – Indian Institute of Chemical Biology, Department of Chemistry, 4 Raja S. C. Mullick Road, Kolkata 700 032, India Email: partha@iicb.res.in

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Abstract

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Abstract

A short and efficient synthetic approach has been developed for the synthesis of a variety of imidazole-fused benzodiazepinones. It is based on a Ugi multicomponent reaction strategy and uses various isocyanides to generate the key intermediates for a Mumm rearrangement process. The method is suitable for rapid syntheses of fused azaheterocycles of pharmacological interest.

Key words

multicomponent reactions - heterocycles - fused-ring systems - isocyanides - imidazoles - rearrangements

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References

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