Synthesis 2015; 47(10): 1423-1435
DOI: 10.1055/s-0034-1380159
paper
© Georg Thieme Verlag Stuttgart · New York

Studies on the Cocatalyst in Ruthenium-Catalyzed C–H Arylation

Masahiko Seki*
Process R&D Department, Healthcare Business Division II, API Corporation, The Kaiteki Bldg., 1-13-4, Uchikanda, Chiyoda-ku, Tokyo 101-0047, Japan   Email: seki.masahiko@mm.api-corp.co.jp
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Publication History

Received: 28 December 2014

Accepted after revision: 16 January 2015

Publication Date:
27 February 2015 (online)


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Abstract

The performance of three types of Brønsted acid potassium salts, potassium carboxylates, potassium phosphates, and potassium sulfonates, has been tested as the cocatalyst in ruthenium-catalyzed C–H arylation. Among them, dipotassium glutarate, potassium bis(2-ethylhexyl) phosphate, and potassium 2,4,6-trimethylbenzenesulfonate provided higher activity. Potassium 2,4,6-trimethylbenzenesulfonate was the most active even for less reactive substrates, such as electron-deficient azoles and sterically demanding aryl bromides.

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