The Reaction of 2-(Acylamino)benzonitriles with Primary Aromatic Amines: A Convenient Synthesis of 2-Substituted 4-(Arylamino)quinazolines

Elina Marinho; M. Fernanda Proença

doi:10.1055/s-0034-1380322

Synthesis, Inhaltsverzeichnis

Synthesis 2015; 47(11): 1623-1632
DOI: 10.1055/s-0034-1380322

paper

The Reaction of 2-(Acylamino)benzonitriles with Primary Aromatic Amines: A Convenient Synthesis of 2-Substituted 4-(Arylamino)quinazolines

Elina Marinho

Chemistry Department, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal eMail: fproenca@quimica.uminho.pt

,

M. Fernanda Proença*

Chemistry Department, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal eMail: fproenca@quimica.uminho.pt

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Abstract

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Abstract

2-Substituted 4-(arylamino)quinazolines were prepared from 2-(acylamino)benzonitriles and primary arylamines by refluxing in either ethanol using trifluoroacetic acid as a catalyst or acetic acid. The 2-aminobenzonitrile was acylated by reaction with anhydrides, isocyanates, or ethyl chloroformate at room temperature.

Key words

acylation - cyclization - heterocycles - 4-aminoquinazolines - 2-aminobenzonitrile

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Referenzen

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