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Synthesis 2015; 47(13): 1913-1921
DOI: 10.1055/s-0034-1380506
DOI: 10.1055/s-0034-1380506
paper
One-Pot Base-Mediated Synthesis of Functionalized Aza-Fused Polycyclic Quinoline Derivatives
Authors
Weitere Informationen
Publikationsverlauf
Received: 15. Dezember 2014
Accepted after revision: 03. März 2015
Publikationsdatum:
02. April 2015 (online)
Abstract
A new one-pot protocol has been developed for the facile and efficient synthesis of aza-fused polycyclic quinolines (e.g., pyrrolo[1,2-a]quinolines) by the base-catalyzed reaction of 2-formylpyrroles and 2-halophenylacetonitriles. This reaction proceeded under transition metal-free conditions and showed high functional group tolerance, with the desired products being formed in good yields.
Key words
one-pot - base-catalyzed - transition metal free - aza-fused polycyclic quinolones - pyrrolo[1,2-a]quinolinesSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380506.
- Supporting Information (PDF)
-
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