Synthesis of Isatins through Direct Oxidation of Indoles with IBX-SO₃K/NaI

Abstract

The direct conversion of indoles into isatins is presented. The reagent mixture NaI/IBX-SO₃K, containing a sulfonylated derivative of 2-iodoxybenzoic acid, was employed to trigger this oxidative process. Moreover, the synthetic route toward IBX-SO₃K and the X-ray crystal structure of the title compound are described in great detail.

Key words

hypervalent iodine - oxidation - indoles - isatins - heterocycles

• References


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