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Synlett 2015; 26(11): 1461-1464
DOI: 10.1055/s-0034-1380715
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© Georg Thieme Verlag Stuttgart · New York

Gold(I)-Catalyzed Domino Cyclization for the Synthesis of Tricyclic Chromones

Zhiqiang Li
a   College of Pharmacy, Jinan University, Guangzhou, P. R. of China   Email: twmchen@jnu.edu.cn
b   Shenzhen Municipal Key Laboratory of Chemical Synthesis of Medicinal Organic Molecules & Shenzhen Center of Novel Functional Molecules, Shenzhen Research Institute, The Chinese University of Hong Kong, No.10, 2nd Yuexing Road, Shenzhen 518507, P. R. of China
,
Qingjiang Li
c   Department of Chemistry, Centre of Novel Functional Molecules and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China   Email: hncwong@cuhk.edu.hk
d   School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. of China
,
Guo-Kai Liu
b   Shenzhen Municipal Key Laboratory of Chemical Synthesis of Medicinal Organic Molecules & Shenzhen Center of Novel Functional Molecules, Shenzhen Research Institute, The Chinese University of Hong Kong, No.10, 2nd Yuexing Road, Shenzhen 518507, P. R. of China
e   Department of Pharmacy, School of Medicine, Shenzhen University, No.3688, Nanhai Road, Nanshan, Shenzhen 518060, P. R. of China
,
Weimin Chen*
a   College of Pharmacy, Jinan University, Guangzhou, P. R. of China   Email: twmchen@jnu.edu.cn
,
Xiao-Shui Peng
b   Shenzhen Municipal Key Laboratory of Chemical Synthesis of Medicinal Organic Molecules & Shenzhen Center of Novel Functional Molecules, Shenzhen Research Institute, The Chinese University of Hong Kong, No.10, 2nd Yuexing Road, Shenzhen 518507, P. R. of China
c   Department of Chemistry, Centre of Novel Functional Molecules and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China   Email: hncwong@cuhk.edu.hk
,
Henry N. C. Wong*
b   Shenzhen Municipal Key Laboratory of Chemical Synthesis of Medicinal Organic Molecules & Shenzhen Center of Novel Functional Molecules, Shenzhen Research Institute, The Chinese University of Hong Kong, No.10, 2nd Yuexing Road, Shenzhen 518507, P. R. of China
c   Department of Chemistry, Centre of Novel Functional Molecules and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China   Email: hncwong@cuhk.edu.hk
› Author Affiliations
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Publication History

Received: 07 March 2015

Accepted after revision: 14 April 2015

Publication Date:
03 June 2015 (online)

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Abstract

A simple and efficient method for the synthesis of tricyclic chromones has been developed. In this approach, tricyclic chromones were synthesized from a diverse range of phenols and alkynes through a Sonogashira coupling and subsequent gold-catalyzed intramolecular domino cyclization.

Key words

chromone - gold-catalyzed - intramolecular cyclization - domino - Brønsted acid

Supporting Information

    Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380715.
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