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Synthesis 2015; 47(16): 2457-2466
DOI: 10.1055/s-0034-1380865
DOI: 10.1055/s-0034-1380865
paper
Palladium-Catalyzed Double C–H Arylation Reaction: Tandem Synthesis of Benzo[a]imidazo[5,1,2-cd]indolizines from Imidazo[1,2-a]pyridines and o-Dihaloarenes
Further Information
Publication History
Received: 06 March 2015
Accepted after revision: 24 April 2015
Publication Date:
19 June 2015 (online)
Abstract
A palladium-catalyzed direct arylation of 2-arylimidazo[1,2-a]pyridines with o-dihaloarenes via double C–H activation is described. The process comprises intermolecular C3-arylation of 2-arylimidazo[1,2-a]pyridines followed by an intramolecular C5-arylation in a highly regioselective fashion, affording benzo[a]imidazo[5,1,2-cd]indolizine derivatives in moderate to good yields.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380865.
- Supporting Information
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