Differenzialdiagnostik und medikamentöse Therapie der Rheumatoiden Arthritis – Rheumatologische und schmerzmedizinische Aspekte

In den letzten 15 Jahren sind neue medikamentöse Behandlungsmöglichkeiten der Rheumatoiden Arthritis entwickelt worden. Dank dieser Therapien ist heute bei einigen Patienten eine komplette Remission möglich. Entscheidend ist allerdings die möglichst frühe Diagnosestellung und eine exakte Differenzialdiagnostik.

• Literatur

• 1 Schneider M, Krüger K. Rheumatoid arthritis – early diagnosis and disease management. Dtsch Arztebl Int 2013; 110: 477-484
• 2 Furst DE, Emery P. Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets. Rheumatology 08.01.2014;
• 3 Burmester GR, Feist E, Dörner T. Emerging cell and cytokine targets in rheumatoid arthritis. Nat Rev Rheumatol 2014; 10: 77-88
• 4 Krüger K, Wollenhaupt J, Burmester GR et al. S1-Leitlinie der DGRh zur sequenziellen medikamentösen Therapie der Rheumatoiden Arthritis. Z Rheumatol 2012; 71: 592-603
• 5 Albrecht K, Krüger K, Wollenhaupt J et al. German guidelines for the sequential medical treatment of rheumatoid arthritis with traditional and biologic disease-modifiying anti-rheumatic drugs. Rheumatol Int 2014; 34: 1-9
• 6 Vazquez E, Kahlenbach J, Segond von Banchet G et al. Spinal interleukin-6 is an amplifier of arthritic pain. Arthritis Rheum 2012; 64: 2233-2242
• 7 König C, Zharsky M, Schaible HG et al. Involvement of peripheral and spinal Tumor necrosis factor alpha (TNF-alpha) in spinal cord hyperexcitability during knee joint inflammation in rat. Arthritis Rheum 18.11.2013;
• 8 Hess A, Axmann R, Schett G et al. Blockade of TNF-α rapidly inhibits pain responses in the central nervous system. Proc Natl Acad Sci USA 2011; 108: 3731-3736
• 9 Aletaha D, Burmester GR, Smolen JS et al. Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010; 62: 2569-2581
• 10 Nielen MM, van Schaardenburg D, Reesink HW et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 2004; 50: 380-386
• 11 Gilliam BE, Moore TL. The role of anti-cyclic citrullinated peptide (CCP) antibodies in early detection of rheumatoid arthritis. Expert Opin Med Diagn 2012; 6: 359-369
• 12 Hartung W, Backhaus M, Ohrndorf S. Joint sonography in rheumatology. Z Rheumatol 2013; 72: 791-801
• 13 Tamas MM, Filippucci E, Grassi W et al. Bone erosions in rheumatoid arthritis: ultrasound findings in the early stage of the disease. Rheumatology 05.02.2014;
• 14 Colebatch AN, Edwards CJ, Østergaard M et al. EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis. Ann Rheum Dis 21.03.2013;
• 15 Werner SG, Langer HE, Backhaus M. Indocyanine green-enhanced fluorescence optical imaging in patients with early and very early arthritis: a comparative study with magnetic resonance imaging. Arthritis Rheum 2013; 65: 3036-3044
• 16 Buttgereit F, Mehta D, Kirwan J et al. Low-dose prednisone chronotherapy for rheumatoid arthritis: a randomized clinical trial (CAPRA-2). Ann Rheum Dis 2013; 72: 204-210
• 17 Freeman R, Baron R, Bouhassira D et al. Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs. Pain 2014; 155: 367-376
• 18 Karst M, Jasper S, Bernateck M, Stephan M. Clinical diagnosis and therapy of chronic pain syndromes. Psychother Psychosom Med Psychol 2012; 62: 320-330
• 19 Zernikow B, Gerhold K, Bürk G et al. Definition, diagnosis and therapy of chronic widespread pain and so called fibromyalgia syndrome in children and adolescents. Systematic literature review and guideline. Schmerz 2012; 26: 318-330
• 20 Stephan M, Karst M, Bernateck M. Medikamentöse Behandlungsstrategien bei chronischen Schmerzen – Schwerpunkt antihyperalgetisch wirksame Substanzen. Psych up date 2014; 8: 37-48