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Planta Med 2014; 80(15): 1304-1309
DOI: 10.1055/s-0034-1382998
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Phragmalin Limonoids from the Stem Barks of Chukrasia tabularis var. velutina

Jun-Lin Yin
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2   University of Chinese Academy of Sciences, Beijing, P. R. China
,
Xin Fang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2   University of Chinese Academy of Sciences, Beijing, P. R. China
,
En-De Liu
3   Department of Biogeography and Ecology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Chun-Mao Yuan
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
4   Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. China
,
Shi-Fei Li
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2   University of Chinese Academy of Sciences, Beijing, P. R. China
,
Yu Zhang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2   University of Chinese Academy of Sciences, Beijing, P. R. China
,
Hong-Ping He
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Shun-Lin Li
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Ying-Tong Di
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Xiao-Jiang Hao
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
› Author Affiliations
Further Information

Publication History

received 21 January 2014
revised 13 June 2014

accepted 29 July 2014

Publication Date:
25 August 2014 (online)

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Abstract

Seven new phragmalin limonoids, chukvelutilides I–O (1–7), were isolated from the stem barks of Chukrasia tabularis var. velutina. Their structures were elucidated by extensive spectroscopic analysis. Among them, compound 1 showed moderate lethal activity against brine shrimp larvae, with an LC50 value of 84.1 µM.

Key words

Chukrasia tabularis - Meliaceae - phragmalin - limonoid - chukvelutilide I - Artemia sinica

Supporting Information

 

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