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Planta Med 2014; 80(17): 1647-1656
DOI: 10.1055/s-0034-1383123
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Hepatoprotective Saikosaponin Homologs from Comastoma pedunculatum

Bao-Song Cui
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Peopleʼs Republic of China
,
Yong-Qi Qiao
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Peopleʼs Republic of China
,
Yi Yuan
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Peopleʼs Republic of China
,
Li Tang
2   College of Life and Environmental Science, Central University for Nationalities, Beijing, Peopleʼs Republic of China
,
Hui Chen
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Peopleʼs Republic of China
,
Yan Li
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Peopleʼs Republic of China
,
Shuai Li
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Peopleʼs Republic of China
› Author Affiliations
Further Information

Publication History

received 22 April 2014
revised 20 July 2014

accepted 01 September 2014

Publication Date:
24 September 2014 (online)

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Abstract

Eight new triterpenoid saponins, the saikosaponin homologs comastomasaponins A–H (1–8), as well as a known triterpenoid (9) and eight known saponins (10–17) were isolated from the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated spectroscopically, and their hepatoprotective activity and cytotoxic activity were evaluated against five human tumor cell lines in vitro. Compounds 1, 5–12, 14, 15, and 17 exhibited potent hepatoprotective activity, and compound 11 displayed cytotoxic activity against HCT-8, Bel-7402, BGC-825, A549, and A2780 human tumor cell lines.

Key words

Gentianaceae - Comastoma pedunculatum - saikosaponin homologs - hepatoprotective activity - cytotoxic activity

Supporting Information

 

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