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Semin Thromb Hemost 2014; 40(06): 652-659
DOI: 10.1055/s-0034-1384635
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Plasminogen Activator Inhibitor-1 in Aging

Koji Yamamoto
1   Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
,
Kyosuke Takeshita
2   Department of Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan
,
Hidehiko Saito
3   Nagoya Medical Center, Nagoya, Japan
› Author Affiliations
Further Information

Publication History

Publication Date:
14 August 2014 (online)

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Abstract

Plasminogen activator inhibitor-1 (PAI-1), a principal inhibitor of fibrinolysis, is induced in thrombotic, fibrotic, and cardiovascular diseases, which in turn primarily afflict the older population. This induction of PAI-1 may play an important role in the pathology of these diseases as PAI-1 can regulate the dissolution of fibrin and also inhibit the degradation of the extracellular matrix by reducing plasmin generation. PAI-1 expression is elevated in aged individuals and is significantly upregulated in a variety of pathologies associated with the process of aging, including myocardial and cerebral infarction, vascular (athero) sclerosis, cardiac and lung fibrosis, metabolic syndromes (e.g., hypertension, hyperlipidemia, and insulin resistance), cancer, and inflammatory/stress responses. Thus, PAI-1 may play a critical role in the development of aging-associated pathological changes. In addition, PAI-1 is recognized as a marker of senescence and a key member of a group of proteins collectively known as the senescence-messaging secretome. In this review, we highlight the role of PAI-1 in the pathophysiology of aging and aging-associated disorders.

Keywords

PAI-1 - thrombosis - fibrosis - vascular sclerosis - metabolic syndrome
 

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