Aging of Platelet Nitric Oxide Signaling: Pathogenesis, Clinical Implications, and Therapeutics

Nathan E. K. Procter; Cher-Rin Chong; Aaron L. Sverdlov; Wai Ping A. Chan; Yuliy Y. Chirkov; John D. Horowitz

doi:10.1055/s-0034-1389082

Seminars in Thrombosis and Hemostasis, Inhaltsverzeichnis

Semin Thromb Hemost 2014; 40(06): 660-668
DOI: 10.1055/s-0034-1389082

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Aging of Platelet Nitric Oxide Signaling: Pathogenesis, Clinical Implications, and Therapeutics

Nathan E. K. Procter

¹Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia

,

Cher-Rin Chong

¹Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia

,

Aaron L. Sverdlov

¹Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia

,

Wai Ping A. Chan

¹Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia

,

Yuliy Y. Chirkov

¹Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia

,

John D. Horowitz

¹Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia

› Institutsangaben

Abstract

The nitric oxide (NO)/soluble guanylate cyclase (sGC) system is fundamental to endothelial control of vascular tone, but also plays a major role in the negative modulation of platelet aggregation. The phenomenon of platelet NO resistance, or decreased antiaggregatory response to NO, occurs increasingly with advanced age, as well as in the context of cardiovascular disease states such as heart failure, ischemic heart disease, and aortic valve disease. The central causes of NO resistance are “scavenging” of NO and dysfunction of sGC. In the current review, we discuss the roles of several modulators of NO synthesis and of the NO/sGC cascade on changes in platelet physiology with aging, together with potential therapeutic options to reduce associated thrombotic risk.

Keywords

platelet aggregation - nitric oxide - aging - cyclic guanosine monophosphate

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