International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2015; 36(07): 579-584
DOI: 10.1055/s-0034-1395588

Training & Testing

© Georg Thieme Verlag KG Stuttgart · New York

Effects of Swimming on the Inflammatory and Redox Response in a Model of Allergic Asthma

T. R. Brüggemann

¹Internal Medicine, School of Medicine of University of São Paulo, São Paulo, Brazil

,

L. C. M. Ávila

²Physical Therapy, State University of Santa Catarina, Florianopolis, Brazil

,

B. Fortkamp

²Physical Therapy, State University of Santa Catarina, Florianopolis, Brazil

,

F. R. Greiffo

³Research, Nove de Julho University – UNINOVE, São Paulo, Brazil

,

F. Bobinski

⁴Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil

,

L. Mazzardo-Martins

⁴Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil

,

D. F. Martins

⁴Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil

,

M. M. M. F. Duarte

⁵Department of Health Science, Lutheran University of Brazil, Santa Maria, Brazil

,

A. Dafre

⁴Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil

,

A. R. S. Santos

⁴Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil

,

M. D. Silva

⁴Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil

,

L. F. Souza

⁴Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil

,

R. P. Vieira

⁶Research, Nove de Julho University, São Paulo, Brazil

,

D. C. Hizume-Kunzler

²Physical Therapy, State University of Santa Catarina, Florianopolis, Brazil

› Author Affiliations

Abstract

In this study we hypothesized that swimming during sensitization phase could result in a preventive effect in mice with allergic asthma. Swiss mice were divided into 4 groups: Control and Swimming (non-sensitized), OVA and OVA+Swimming (sensitized). The allergic inflammation was induced by 2 intraperitoneal injections and 4 aerosol challenges using ovalbumin. Swimming sessions were performed at high intensity over 3 weeks. 48 h after the last challenge mice were euthanized. Swimming decreased OVA-increased total IgE, IL-1, IL-4, IL-5 and IL-6 levels, as well as the number of total cells, lymphocytes and eosinophils in bronchoalveolar lavage fluid, (p<0.05). Simultaneously, swimming also increased IL-10 and glutathione levels in the Swimming and OVA+Swimming groups (p<0.05). The levels of glutathione peroxidase and catalase were increased only in the Swimming group when compared to all groups (p<0.05). 21 days of swimming resulted in an attenuation of pulmonary allergic inflammation followed by an increase of glutathione levels in the OVA group. Swimming only increased the levels of glutathione peroxidase and catalase in non-sensitized mice (p<0.05). These data suggest that the pulmonary anti-inflammatory effects produced by 3 weeks of high-intensity swimming in this model of OVA-induced asthma may be, at least partly, modulated by reduced oxidative stress and increased IL-10 production.

Key words

Key words

swimming - antioxidant system - pulmonary inflammation

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