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Am J Perinatol 2015; 32(09): 895-904
DOI: 10.1055/s-0035-1544948
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Antioxidants and Biomarkers of Oxidative Stress in Preterm Infants with Symptomatic Patent Ductus Arteriosus

Musaddaq Inayat
1   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of California, Irvine, California
,
Fayez Bany-Mohammed
1   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of California, Irvine, California
,
Arwin Valencia
2   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Miller Children's Hospital, Long Beach, California
,
Ching Tay
2   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Miller Children's Hospital, Long Beach, California
,
Josefina Jacinto
2   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Miller Children's Hospital, Long Beach, California
,
Jacob V. Aranda
3   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, New York
4   Department of Ophthalmology, State University of New York, Downstate Medical Center, Brooklyn, New York
5   State University of New York Eye Institute, NY, New York
,
Kay D. Beharry
3   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, New York
4   Department of Ophthalmology, State University of New York, Downstate Medical Center, Brooklyn, New York
5   State University of New York Eye Institute, NY, New York
› Author Affiliations
Further Information

Publication History

11 August 2014

19 December 2014

Publication Date:
25 February 2015 (online)

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Abstract

Objective Immature antioxidant and oxygen-sensing mechanisms are involved in the pathogenesis of the patent ductus arteriosus (PDA). We conducted a prospective, observational, pilot study to test the hypothesis that antioxidant activity is low at birth in preterm infants at risk for symptomatic PDA.

Study Design Blood and urine samples were collected within 24 to 48 hours of life in 53 preterm infants (≤32 weeks' gestation) who developed early PDA symptoms and in 30 term (≥37 weeks' gestation) control infants. Thirty preterm infants developed hemodynamically significant PDA (hsPDA) and required pharmacologic treatment and/or PDA ligation. For these infants, blood and urine samples were also collected at 24 hours posttreatment. Samples were analyzed for biomarkers of antioxidant activity, oxidative stress, and lipid peroxidation.

Results At 24 to 48 hours after birth, plasma superoxide dismutase (SOD), urinary catalase, and plasma and urinary 8-isoPGF2α were significantly lower in preterm infants who developed hsPDA. Plasma 8-isoPGF2α levels rebounded post–PDA treatment, while urinary prostaglandin E2, plasma and urinary thromboxane B2, and plasma SOD declined.

Conclusion The antioxidant status is low in preterm infants at risk for developing hsPDA. SOD may be a key antioxidant regulating functional ductus arteriosus closure. Therefore, low levels may result in persistence of a hsPDA.

Keywords

antioxidant - oxidative stress - patent ductus arteriosus - premature infants
 

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