Am J Perinatol 2015; 32(12): 1126-1132
DOI: 10.1055/s-0035-1549217
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids

K.S. Borowski
1   Departments of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa
,
E.A.S. Clark
2   University of Utah, Salt Lake City, Utah
,
Y. Lai
3   The George Washington University Biostatistics Center, Washington, District of Columbia
,
R.J. Wapner
4   Drexel University, Philadelphia, Pennsylvania
,
Y. Sorokin
5   Wayne State University, Detroit, Michigan
,
A.M. Peaceman
6   Departments of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois
,
J.D. Iams
7   Departments of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio
,
K.J. Leveno
8   Departments of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas
,
M. Harper
9   Departments of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, North Carolina
,
S.N. Caritis
10   Departments of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania
,
M. Miodovnik
11   Columbia University, New York, New York
12   Departments of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio
,
B.M. Mercer
13   Departments of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio
,
J.M. Thorp Jr.
14   University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
,
M.J. O'Sullivan
15   University of Miami, Miami, Florida
,
S.M. Ramin
16   The University of Texas Health Science Center at Houston, Houston, Texas
,
M.W. Carpenter
17   Departments of Obstetrics and Gynecology, Brown University, Providence, Rhode Island
,
D.J. Rouse
18   University of Alabama at Birmingham, Birmingham, Alabama
,
B. Sibai
19   Departments of Obstetrics and Gynecology, University of Tennessee, Memphis, Tennessee
,
for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network› Institutsangaben
Weitere Informationen

Publikationsverlauf

13. Dezember 2014

24. Februar 2015

Publikationsdatum:
08. Mai 2015 (online)

Preview

Abstract

Objective The aim of the study is to evaluate the association of steroid metabolism and respiratory gene polymorphisms in neonates exposed to antenatal corticosteroids (ACS) with respiratory outcomes, small for gestational age (SGA), and response to repeat ACS.

Study Design This candidate gene study is a secondary analysis of women enrolled in a randomized controlled trial of single versus weekly courses of ACS. Nineteen single nucleotide polymorphisms (SNPs) in 13 steroid metabolism and respiratory function genes were evaluated. DNA was extracted from placenta or fetal cord serum and analyzed with TaqMan genotyping. Each SNP was evaluated for association via logistic regression with respiratory distress syndrome (RDS), continuous positive airway pressure (CPAP)/ventilator use (CPV), and SGA.

ResultsCRHBP, CRH, and CRHR1 minor alleles were associated with an increased risk of SGA. HSD11B1 and SCNN1B minor alleles were associated with an increased likelihood of RDS. Carriage of minor alleles in SerpinA6 was associated with an increased risk of CPV. CRH and CRHR1 minor alleles were associated with a decreased likelihood of CPV.

Conclusion Steroid metabolism and respiratory gene SNPs are associated with respiratory outcomes and SGA in patients exposed to ACS. Risks for respiratory outcomes are affected by minor allele carriage as well as by treatment with multiple ACS.

* Other members of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network are listed in the Appendix.


Supplementary Material