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DOI: 10.1055/s-0035-1551676
Cardiac Surgery in Germany during 2014: A Report on Behalf of the German Society for Thoracic and Cardiovascular Surgery
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Publication History
24 March 2015
27 March 2015
Publication Date:
26 May 2015 (online)
Abstract
Based on a voluntary registry of the German Society for Thoracic and Cardiovascular Surgery (GSTCVS), data of all heart surgery procedures performed in 78 German cardiac surgical units during the year 2014 are presented. In 2014, a total of 100,398 cardiac surgical procedures (implantable cardioverter-defibrillator and pacemaker procedures excluded) were submitted to the registry. More than 14.2% of the patients were older than 80 years, describing an increase of 0.4% compared with the previous year. The unadjusted in-hospital mortality for 40,006 isolated coronary artery bypass grafting procedures (84.7% on-pump, 15.3% off-pump) was 2.6%. In 31,359 isolated valve procedures (including 9,194 catheter-based procedures), an in-hospital mortality of 4.4% was observed. This annual updated registry of the GSTCVS is published since 1989. It is an important tool for quality assurance and voluntary public reporting by illustrating current standards and actual developments for nearly all cardiac surgical procedures in Germany.
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Keywords
cardiac surgery - outcome - registry - heart valve surgery - congenital heart disease - aortic surgeryIntroduction
Legitimate demands for a sophisticated quality assurance in medicine—by patients, relatives, insurance companies, and authorities all over the world—have stimulated the development of a wide range of registries and other activities to answer those needs. As early as 1978, the board of directors of the German Society for Thoracic and Cardiovascular Surgery (GSTCVS; www.dgthg.de) (www.dgthg.de) decided to set up an annually updated database of all cardiac surgical procedures in terms of a voluntary registry. Since 1989, the annually updated data of the registry are published in the scientific journal of the GSTCVS.[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] The aims of this registry are to gather developments and current trends in cardiac surgery in Germany, compiling various results for nearly all cardiac surgical procedures, enabling each participating cardiac surgical unit a comparison of its own results to the nationwide achievements, and enabling an evaluation on an international level for the society.
For monitoring actual conditions as well as the development in cardiac medicine, the registry covers all relevant techniques and also innovative technologies including off-pump cardiac surgery, minimally invasive heart valve operations, and transcatheter aortic valve implantations [TAVI]. Thereby important findings for current patient safety and the future of patient care may be collected and evaluated.
Data and results presented in this report comprehend assorted data of the year 2014.
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Materials and Methods
Since 2004, a standardized questionnaire gathers detailed information about each individual procedure exactly defined by an annually updated German adaption of the International Classification of Procedures in Medicine (ICPM) called operation code (OPS—Operationen- und Prozedurenschlüssel).
All participants were requested to complete the structured questionnaire until January 16, 2015, asking for all performed procedures and associated in-hospital mortality. The recommended path for data export is an electronic transmission of an encrypted file which has to be addressed to the office of the GSTCVS in Berlin. After transaction, the data are decrypted, evaluated for completeness, and compiled for further analysis, thus ensuring anonymity for each participating institution. This compilation algorithm guarantees a high compliance for submission of complete datasets.
Inclusion criteria for the registry 2014 were all patients receiving cardiac surgical procedures performed between January 1, 2014, and December 31, 2014, unrelated to the date of admission or discharge as compared with other registries. Alike to all previous years, the number of procedures was counted rather than individual patients. For example, if a patient required additional coronary bypass grafting due to a complication after initial aortic valve replacement during one admission, one count in the category “aortic valve replacement” and another in the category “coronary surgery” are enumerated. Thus, the registry contains more procedures than the real number of operated patients.
Death of patients was defined as in-hospital mortality. Per definition, the observed mortality is always attributed to the first cardiac procedure; for example, the death of a patient requiring coronary bypass grafting due to a complication of an aortic valve procedure would only be attributed to the aortic valve procedure.
The main reason for this structural setup of the registry—established over several decades—is to keep in accordance with the German data privacy act with its specific regulations for patients. Furthermore, it seemed to be relevant to get detailed information about all performed procedures and not only the number of treated patients. Last but not least, the process of data acquisition had to be standardized and feasible for all cardiac surgery units in Germany, thus enabling the submission of a complete dataset, regardless of the locally existing hard- and software used for data management.
In 2014, a total of 78 institutions performed heart surgery. Fortunately all units answered the questionnaire and delivered a complete dataset for the year 2014 including hospital mortality rates.
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Registry Data 2014
[Table 1] illustrates the development of procedures using extracorporeal circulation (ECC) in Germany over one decade. Since 2010, the number of heart operations using ECC shows only a slight decline.
Overall 187,392 procedures were reported to the registry for the year 2014, an increase of 3.9% (2013: 180,367 procedures). A total of 104,484 cardiac surgical procedures (excluded: ICD, pacemakers and miscellaneous procedures without ECC) reveal an increase of 1.6% (n = 1,639) compared with the year 2013 (102,845 procedures) ([Table 2]). [Tables 3] to [4] [5], [V1] to [V2] [V3] [V4] [V5] [V6] [V7], [C1] to [C2], [C3], [Table Con1] and [Con2], and [Table Mis 1] to [Mis 2] [Mis 3] [Mis 4] [Mis 5] and [Figs. 1] [2] [3] [4] [5] [6] [7] [8] [9] demonstrate the compiled registry data of 2014 for various categories.
Compared to the data of previous years, several important developments continued in 2014 almost unchanged. Over the past 10 years, the age distribution of patients ([Fig. 6]) showed a shift to elderly patients with presently 54.3% of the cardiac procedures performed in patients of at least 70 years of age and 14.2% in patients of 80 years or older. However, mortality remained on the same low level or even decreased slightly over the last decade ([Fig. 2]). The rate of coronary artery bypass grafting (CABG) procedures decreased over the past years while the relative number of off-pump CABG showed no relevant variation (2014: 15.3%, 2013: 15.5%) ([Fig. 3]).
Since 2004, more than 50% of isolated mitral valve procedures were reconstructions. In 2014, the mitral valve reconstruction rate was 65.7% ([Fig. 8]). Based on the fact that all isolated mitral valve procedures are included in this registry, these data have to be interpreted with caution. Regardless of the underlying valve disease/morphology or urgency of operation, it has to be assumed that the relative rate of mitral valve reconstruction would certainly be even higher if patients without possibility or indication for reconstruction would have been excluded (e.g., mitral valve stenosis, calcifications, or endocarditis). In other publications, [26] patients with mitral valve stenosis, endocarditis, and emergency procedures were excluded.
The continued increase of left ventricular assist device implantations ([Fig. 10]) emphasizes the increasing relevance of mechanical circulatory support.
Again a remarkable trend is the still ongoing increase of TAVI procedures in Germany ([Fig. 5]), while the number of isolated aortic valve replacement procedures remained on a nearly unchanged level. Starting in 2006 with just 78 implantations (0.67% of isolated aortic valve procedures), in 2014 a total of 8,631 (42.3%) TAVIs were reported to the registry. It must be emphasized that the 78 institutions which contribute their data to this registry do not represent all departments performing TAVI in Germany. It is well known that some additional institutions in Germany perform TAVI procedures under different infrastructure conditions and various external cooperations. This practice does not correlate to the recommendations of the European guideline[27] on the management of valvular heart disease. Considering this background, on January 22, 2015, the Federal Joint Committee (G-BA)—as the highest decision-making body of the joint self-government in Germany—issued the first version of the quality assurance directive for “minimal invasive heart valve interventions (TAVI, Mitral Clip reconstruction)” in which obligatory structures, defined processes, and qualified personnel are exactly specified.[28]
In addition, the short-, mid-, and long-term results of the German Aortic Valve Registry (GARY)[29] [30] [31] [32] [33] and the annual analyses of the legal quality assurance (§137 SGB V) are of outstanding patient benefit.
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Discussion
The registry of the GSTCVS enables a comprehensive overview of all cardiac surgical procedures performed in Germany during 2014. The accuracy of this registry is considered to be high due to the implemented compilation algorithm using standardized operation coding as a relevant criterion for reimbursement purposes. This is supported by other authors who could demonstrate a high accuracy for major outcome parameters in unaudited registries.[30] In continuation with previous years, it can be concluded that cardiac surgery in Germany is performed on a constantly high level with high in-hospital survival rates compared with other international registries. This conclusion is especially important in an era of demographic change of the German population, resulting in a continuous increase of patient age and related comorbidities, both leading to a higher preoperative risk profile.
Compared with 2013, the count of cardiac surgery procedures remains almost on the same level, which is partly due to the still increasing number of catheter-based heart valve procedures.
Further improvements in the basic configuration of the registry are recommended to enable a more detailed and particularly a risk-adjusted data analyses.[34] However, if significant structural changes of data collection for the registry are conducted, it must be ensured that data compatibility still allows further longitudinal data analysis.
Completeness, validity, and further developments will depend on continued efforts of the GSTCVS in close collaboration with all cardiac surgical units in Germany. This will be of outstanding importance in the sense of a contribution for patient safety and to adduce evidence for the quality of cardiac surgery in Germany.
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Table V1 has been corrected in the above article as per erratum published online on June 10, 2015. DOI of erratum is: 10.1055/s-0035-1556566.
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Acknowledgments
On behalf of the German Society for Thoracic and Cardiovascular Surgery, the authors would like to thank the heads of departments of all cardiac surgery units in Germany and their employees for their continued cooperation and support to realize this registry.
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References
- 1 Kalmar P, Irrgang E. Cardiac surgery in the Federal Republic of Germany during 1989. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1990; 38 (3) 198-200
- 2 Kalmar P, Irrgang E. Cardiac surgery in the Federal Republic of Germany during 1990. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1991; 39 (3) 167-169
- 3 Kalmar P, Irrgang E. Cardiac surgery in Germany during 1991. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1992; 40 (3) 163-165
- 4 Kalmar P, Irrgang E. Cardiac surgery in Germany during 1992. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1993; 41 (3) 202-204
- 5 Kalmar P, Irrgang E. Cardiac surgery in Germany during 1993. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1994; 42 (3) 194-196
- 6 Kalmar P, Irrgang E. Cardiac surgery in Germany during 1994. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1995; 43 (3) 181-183
- 7 Kalmár P, Irrgang E. Cardiac surgery in Germany during 1995. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1996; 44 (3) 161-164
- 8 Kalmár P, Irrgang E. Cardiac surgery in Germany during 1996. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1997; 45 (3) 134-137
- 9 Kalmár P, Irrgang E. Cardiac surgery in Germany during 1997. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1998; 46 (5) 307-310
- 10 Kalmàr P, Irrgang E. Cardiac surgery in Germany during 1998. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1999; 47 (4) 260-263
- 11 Kalmár P, Irrgang E. Cardiac surgery in Germany during 1999. Thorac Cardiovasc Surg 2000; 48 (4) XXVII-XXX
- 12 Kalmar P, Irrgang E. Cardiac surgery in Germany during 2000. Thorac Cardiovasc Surg 2001; 49 (5) 33-38
- 13 Kalmár P, Irrgang E. Cardiac surgery in Germany during 2001: a report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2002; 50 (6) 30-35
- 14 Kalmár P, Irrgang E ; German Society for Thoracic and Cardiovascular Surgery. Cardiac surgery in Germany during 2002: a report by German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2003; 51 (5) 25-29
- 15 Kalmár P, Irrgang E ; German Society for Thoracic and Cardiovascular Surgery. Cardiac surgery in Germany during 2003: a report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2004; 52 (5) 312-317
- 16 Gummert JF, Funkat A, Krian A. Cardiac surgery in Germany during 2004: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2005; 53 (6) 391-399
- 17 Gummert JF, Funkat A, Beckmann A, Hekmat K, Ernst M, Krian A. Cardiac surgery in Germany during 2005: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2006; 54 (5) 362-371
- 18 Gummert JF, Funkat A, Beckmann A , et al. Cardiac surgery in Germany during 2006: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2007; 55 (6) 343-350
- 19 Gummert JF, Funkat A, Beckmann A , et al; German Society for Thoracic and Cardiovascular Surgery. Cardiac surgery in Germany during 2007: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2008; 56 (6) 328-336
- 20 Gummert JF, Funkat A, Beckmann A , et al. Cardiac surgery in Germany during 2008. A report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2009; 57 (6) 315-323
- 21 Gummert JF, Funkat A, Beckmann A , et al. Cardiac surgery in Germany during 2009. A report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2010; 58 (7) 379-386
- 22 Gummert JF, Funkat AK, Beckmann A , et al. Cardiac surgery in Germany during 2010: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2011; 59 (5) 259-267
- 23 Funkat AK, Beckmann A, Lewandowski J , et al. Cardiac surgery in Germany during 2011: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2012; 60 (6) 371-382
- 24 Beckmann A, Funkat AK, Lewandowski J , et al. Cardiac surgery in Germany during 2012: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2014; 62 (1) 5-17
- 25 Funkat A, Beckmann A, Lewandowski J , et al. Cardiac surgery in Germany during 2013: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2014; 62 (5) 380-392
- 26 Gammie JS, Zhao Y, Peterson ED, O'Brien SM, Rankin JS, Griffith BPJ. J. Maxwell Chamberlain Memorial Paper for adult cardiac surgery. Less-invasive mitral valve operations: trends and outcomes from the Society of Thoracic Surgeons Adult Cardiac Surgery Database. Ann Thorac Surg 2010; 90 (5) 1401-1408 , 1410.e1, discussion 1408–1410
- 27 Vahanian A, Alfieri O, Andreotti F , et al; Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC); European Association for Cardio-Thoracic Surgery (EACTS). Guidelines on the management of valvular heart disease (version 2012). Eur Heart J 2012; 33 (19) 2451-2496
- 28 G-BA Richtlinie zu minimalinvasiven Herzklappeninterventionen. Available at: https://www.g-ba.de/informationen/beschluesse/2165/
- 29 Beckmann A, Hamm C, Figulla HR , et al; GARY Executive Board. The German Aortic Valve Registry (GARY): a nationwide registry for patients undergoing invasive therapy for severe aortic valve stenosis. Thorac Cardiovasc Surg 2012; 60 (5) 319-325
- 30 Hamm CW, Möllmann H, Holzhey D , et al; GARY-Executive Board. The German Aortic Valve Registry (GARY): in-hospital outcome. Eur Heart J 2014; 35 (24) 1588-1598
- 31 Mohr FW, Holzhey D, Möllmann H , et al; GARY Executive Board. The German Aortic Valve Registry: 1-year results from 13,680 patients with aortic valve disease. Eur J Cardiothorac Surg 2014; 46 (5) 808-816
- 32 Lauten A, Figulla HR, Möllmann H , et al; GARY Executive Board. TAVI for low-flow, low-gradient severe aortic stenosis with preserved or reduced ejection fraction: a subgroup analysis from the German Aortic Valve Registry (GARY). EuroIntervention 2014; 10 (7) 850-859
- 33 Walther T, Hamm CW, Schuler G , et al; GARY executive board. Peri-operative results and complications in 15,964 transcatheter aortic valve implantations from the German Aortic valve RegistrY (GARY). J Am Coll Cardiol 2015; . doi: 10.1016/j.jacc.2015.03.034
- 34 Herbert MA, Prince SL, Williams JL, Magee MJ, Mack MJ. Are unaudited records from an outcomes registry database accurate?. Ann Thorac Surg 2004; 77 (6) 1960-1964 , discussion 1964–1965
Address for correspondence
-
References
- 1 Kalmar P, Irrgang E. Cardiac surgery in the Federal Republic of Germany during 1989. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1990; 38 (3) 198-200
- 2 Kalmar P, Irrgang E. Cardiac surgery in the Federal Republic of Germany during 1990. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1991; 39 (3) 167-169
- 3 Kalmar P, Irrgang E. Cardiac surgery in Germany during 1991. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1992; 40 (3) 163-165
- 4 Kalmar P, Irrgang E. Cardiac surgery in Germany during 1992. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1993; 41 (3) 202-204
- 5 Kalmar P, Irrgang E. Cardiac surgery in Germany during 1993. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1994; 42 (3) 194-196
- 6 Kalmar P, Irrgang E. Cardiac surgery in Germany during 1994. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1995; 43 (3) 181-183
- 7 Kalmár P, Irrgang E. Cardiac surgery in Germany during 1995. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1996; 44 (3) 161-164
- 8 Kalmár P, Irrgang E. Cardiac surgery in Germany during 1996. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1997; 45 (3) 134-137
- 9 Kalmár P, Irrgang E. Cardiac surgery in Germany during 1997. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1998; 46 (5) 307-310
- 10 Kalmàr P, Irrgang E. Cardiac surgery in Germany during 1998. A report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 1999; 47 (4) 260-263
- 11 Kalmár P, Irrgang E. Cardiac surgery in Germany during 1999. Thorac Cardiovasc Surg 2000; 48 (4) XXVII-XXX
- 12 Kalmar P, Irrgang E. Cardiac surgery in Germany during 2000. Thorac Cardiovasc Surg 2001; 49 (5) 33-38
- 13 Kalmár P, Irrgang E. Cardiac surgery in Germany during 2001: a report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2002; 50 (6) 30-35
- 14 Kalmár P, Irrgang E ; German Society for Thoracic and Cardiovascular Surgery. Cardiac surgery in Germany during 2002: a report by German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2003; 51 (5) 25-29
- 15 Kalmár P, Irrgang E ; German Society for Thoracic and Cardiovascular Surgery. Cardiac surgery in Germany during 2003: a report by the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2004; 52 (5) 312-317
- 16 Gummert JF, Funkat A, Krian A. Cardiac surgery in Germany during 2004: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2005; 53 (6) 391-399
- 17 Gummert JF, Funkat A, Beckmann A, Hekmat K, Ernst M, Krian A. Cardiac surgery in Germany during 2005: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2006; 54 (5) 362-371
- 18 Gummert JF, Funkat A, Beckmann A , et al. Cardiac surgery in Germany during 2006: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2007; 55 (6) 343-350
- 19 Gummert JF, Funkat A, Beckmann A , et al; German Society for Thoracic and Cardiovascular Surgery. Cardiac surgery in Germany during 2007: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2008; 56 (6) 328-336
- 20 Gummert JF, Funkat A, Beckmann A , et al. Cardiac surgery in Germany during 2008. A report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2009; 57 (6) 315-323
- 21 Gummert JF, Funkat A, Beckmann A , et al. Cardiac surgery in Germany during 2009. A report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2010; 58 (7) 379-386
- 22 Gummert JF, Funkat AK, Beckmann A , et al. Cardiac surgery in Germany during 2010: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2011; 59 (5) 259-267
- 23 Funkat AK, Beckmann A, Lewandowski J , et al. Cardiac surgery in Germany during 2011: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2012; 60 (6) 371-382
- 24 Beckmann A, Funkat AK, Lewandowski J , et al. Cardiac surgery in Germany during 2012: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2014; 62 (1) 5-17
- 25 Funkat A, Beckmann A, Lewandowski J , et al. Cardiac surgery in Germany during 2013: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2014; 62 (5) 380-392
- 26 Gammie JS, Zhao Y, Peterson ED, O'Brien SM, Rankin JS, Griffith BPJ. J. Maxwell Chamberlain Memorial Paper for adult cardiac surgery. Less-invasive mitral valve operations: trends and outcomes from the Society of Thoracic Surgeons Adult Cardiac Surgery Database. Ann Thorac Surg 2010; 90 (5) 1401-1408 , 1410.e1, discussion 1408–1410
- 27 Vahanian A, Alfieri O, Andreotti F , et al; Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC); European Association for Cardio-Thoracic Surgery (EACTS). Guidelines on the management of valvular heart disease (version 2012). Eur Heart J 2012; 33 (19) 2451-2496
- 28 G-BA Richtlinie zu minimalinvasiven Herzklappeninterventionen. Available at: https://www.g-ba.de/informationen/beschluesse/2165/
- 29 Beckmann A, Hamm C, Figulla HR , et al; GARY Executive Board. The German Aortic Valve Registry (GARY): a nationwide registry for patients undergoing invasive therapy for severe aortic valve stenosis. Thorac Cardiovasc Surg 2012; 60 (5) 319-325
- 30 Hamm CW, Möllmann H, Holzhey D , et al; GARY-Executive Board. The German Aortic Valve Registry (GARY): in-hospital outcome. Eur Heart J 2014; 35 (24) 1588-1598
- 31 Mohr FW, Holzhey D, Möllmann H , et al; GARY Executive Board. The German Aortic Valve Registry: 1-year results from 13,680 patients with aortic valve disease. Eur J Cardiothorac Surg 2014; 46 (5) 808-816
- 32 Lauten A, Figulla HR, Möllmann H , et al; GARY Executive Board. TAVI for low-flow, low-gradient severe aortic stenosis with preserved or reduced ejection fraction: a subgroup analysis from the German Aortic Valve Registry (GARY). EuroIntervention 2014; 10 (7) 850-859
- 33 Walther T, Hamm CW, Schuler G , et al; GARY executive board. Peri-operative results and complications in 15,964 transcatheter aortic valve implantations from the German Aortic valve RegistrY (GARY). J Am Coll Cardiol 2015; . doi: 10.1016/j.jacc.2015.03.034
- 34 Herbert MA, Prince SL, Williams JL, Magee MJ, Mack MJ. Are unaudited records from an outcomes registry database accurate?. Ann Thorac Surg 2004; 77 (6) 1960-1964 , discussion 1964–1965