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Journal of Pediatric Biochemistry 2015; 05(01): 034-037
DOI: 10.1055/s-0035-1554779
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Measurement of Serum Osteopontin and Interleukin-17 in Asthmatic Children in Saudi Arabia

Ali Khairallah Alzahrani
1   Department of Paediatrics and Neonatology, Taif University, Al Taif, Saudi Arabia
,
Nader Mohammed Mohammed
1   Department of Paediatrics and Neonatology, Taif University, Al Taif, Saudi Arabia
2   Department of Paediatrics, Zagazig General Hospital, Zagazig, Egypt
,
Humaid Al-Swat
3   Children Hospital, Al Taif, Saudi Arabia
,
Rehab Ahmed Karam
4   Department of Biochemistry, Taif University, Al Taif, Saudi Arabia
5   Department of Biochemistry, Zagazig University, Zagazig, Egypt
› Author Affiliations
Further Information

Publication History

Publication Date:
03 July 2015 (online)

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Abstract

Cytokines play an important role in the pathophysiology of asthma by affecting airway remodeling and allergic reactions. We aimed to measure the serum concentrations of osteopontin (OPN) and interleukin (IL)-17 in a group of asthmatic and normal children to test the association of these two cytokines with the severity of asthma in Saudi children. Our study included 50 asthmatic and 50 normal children. Serum cytokines were measured by ELISA technique. Pulmonary function tests were performed in the asthmatic children. Serum levels of OPN and IL-17 were significantly increased in asthmatic children in comparison to control group. Also, the concentrations of OPN and IL-17 were significantly associated with asthma severity. There was a significant positive correlation between OPN and IL-17 levels. In conclusion, our study suggests that OPN and IL-17 may play a role in childhood asthma and are strongly related to the disease severity.

Keywords

interleukin-17 - osteopontin - bronchial asthma
 

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