Measurement of Serum Osteopontin and Interleukin-17 in Asthmatic Children in Saudi Arabia

Ali Khairallah Alzahrani; Nader Mohammed Mohammed; Humaid Al-Swat; Rehab Ahmed Karam

doi:10.1055/s-0035-1554779

Journal of Pediatric Biochemistry, Table of Contents

Journal of Pediatric Biochemistry 2015; 05(01): 034-037
DOI: 10.1055/s-0035-1554779

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Measurement of Serum Osteopontin and Interleukin-17 in Asthmatic Children in Saudi Arabia

Ali Khairallah Alzahrani

¹Department of Paediatrics and Neonatology, Taif University, Al Taif, Saudi Arabia

,

Nader Mohammed Mohammed

¹Department of Paediatrics and Neonatology, Taif University, Al Taif, Saudi Arabia

²Department of Paediatrics, Zagazig General Hospital, Zagazig, Egypt

,

Humaid Al-Swat

³Children Hospital, Al Taif, Saudi Arabia

,

Rehab Ahmed Karam

⁴Department of Biochemistry, Taif University, Al Taif, Saudi Arabia

⁵Department of Biochemistry, Zagazig University, Zagazig, Egypt

› Author Affiliations

Abstract

Cytokines play an important role in the pathophysiology of asthma by affecting airway remodeling and allergic reactions. We aimed to measure the serum concentrations of osteopontin (OPN) and interleukin (IL)-17 in a group of asthmatic and normal children to test the association of these two cytokines with the severity of asthma in Saudi children. Our study included 50 asthmatic and 50 normal children. Serum cytokines were measured by ELISA technique. Pulmonary function tests were performed in the asthmatic children. Serum levels of OPN and IL-17 were significantly increased in asthmatic children in comparison to control group. Also, the concentrations of OPN and IL-17 were significantly associated with asthma severity. There was a significant positive correlation between OPN and IL-17 levels. In conclusion, our study suggests that OPN and IL-17 may play a role in childhood asthma and are strongly related to the disease severity.

Keywords

interleukin-17 - osteopontin - bronchial asthma

Full Text

References

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