Is Serum Serotonin Involved in the Bone Loss of Young Females with Anorexia Nervosa?

L. Maïmoun; S. Guillaume; P. Lefebvre; P. Philibert; H. Bertet; M.-C. Picot; P. Courtet; D. Mariano-Goulart; E. Renard; C. Sultan

doi:10.1055/s-0035-1559632

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2016; 48(03): 174-177
DOI: 10.1055/s-0035-1559632

Endocrine Care

Is Serum Serotonin Involved in the Bone Loss of Young Females with Anorexia Nervosa?

L. Maïmoun

¹Département de Médecine Nucléaire, Hôpital Lapeyronie, Centre Hospitalier Régional Universitaire (CHRU) Montpellier, Montpellier, France

²PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214. 34295 Montpellier cedex 5, France

,

S. Guillaume

³Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHRU Montpellier, UMI, INSERM, Montpellier, France

,

P. Lefebvre

⁴Departement d’Endocrinologie, Diabète, Nutrition, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France

,

P. Philibert

⁵Departement de Biochimie et d’Hormonologie, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France

,

H. Bertet

⁶Unité de Recherche Clinique et Epidémiologie, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France

,

M.-C. Picot

⁶Unité de Recherche Clinique et Epidémiologie, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France

⁷CIC INSERM, Hôpital Gui de Chauliac, CHRU Montpellier, Montpellier, France

,

P. Courtet

³Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHRU Montpellier, UMI, INSERM, Montpellier, France

,

D. Mariano-Goulart

¹Département de Médecine Nucléaire, Hôpital Lapeyronie, Centre Hospitalier Régional Universitaire (CHRU) Montpellier, Montpellier, France

²PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214. 34295 Montpellier cedex 5, France

,

E. Renard

⁴Departement d’Endocrinologie, Diabète, Nutrition, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France

⁷CIC INSERM, Hôpital Gui de Chauliac, CHRU Montpellier, Montpellier, France

⁸Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier 1 et 2, Montpellier, France

,

C. Sultan

⁹Unité d’Endocrinologie et Gynécologie Pédiatrique, Département de Pédiatrie, Hôpital Arnaud de Villeneuve, CHRU Montpellier et UMI, Montpellier, France

› Author Affiliations

Abstract

Recent experimental data suggest that circulating serotonin interacts with bone metabolism, although this is less clear in humans. This study investigated whether serum serotonin interferes with bone metabolism in young women with anorexia nervosa (AN), a clinical model of energy deprivation. Serum serotonin, markers of bone turnover [osteocalcin (OC), procollagen type I N-terminal propeptide (PINP), type I-C telopeptide breakdown products (CTX)], leptin, soluble leptin receptor (sOB-R), and insulin-like growth factor-1 (IGF-1) and its binding protein (IGFBP-3) were assessed. Whole body, spine, hip, and radius areal bone mineral density BMD (aBMD) were assessed by dual-energy X-ray absorptiometry in 21 patients with AN and 19 age-matched controls. Serum serotonin, leptin, IGF-1, IGFBP-3, OC, PINP, and aBMD at all sites, radius excepted, were significantly reduced in AN whereas CTX and sOB-R were increased compared with controls. Serum serotonin levels were positively correlated with weight, body mass index, whole body fat mass, leptin, and IGF-1, and negatively with CTX for the entire population. Low serum serotonin levels are observed in patients with AN. Although no direct link between low serum serotonin levels and bone mass was identified in these patients, the negative relationship between serotonin and markers of bone resorption found in all population nevertheless suggests the implication of serotonin in bone metabolism. Impact of low serum serotonin on bone in AN warrants further studies.

Key words

anorexia nervosa - bone demineralization - serotonin - bone remodeling markers - bone mineral density

Full Text

References

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