Combined Asymmetric Aminocatalysis and Carbene Catalysis

Jing Gu; Wei Du; Ying-Chun Chen

doi:10.1055/s-0035-1560354

Synthesis, Inhaltsverzeichnis

Synthesis 2015; 47(22): 3451-3459
DOI: 10.1055/s-0035-1560354

short review

Combined Asymmetric Aminocatalysis and Carbene Catalysis

Jing Gu

Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. of China eMail: ycchen@scu.edu.cn

,

Wei Du

Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. of China eMail: ycchen@scu.edu.cn

,

Ying-Chun Chen*

Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. of China eMail: ycchen@scu.edu.cn

› Institutsangaben

Abstract

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Abstract

The use of multiple catalytic systems for cascade reactions has found widespread application in recent years. The combination of two important organocatalysts, chiral amines and N-heterocyclic carbenes (NHCs), is of extraordinary interest since they can both potentially mediate a variety of reactions with aldehyde derivatives. In this short review, we discuss the successful combination of asymmetric aminocatalysis and carbene catalysis in the efficient construction of complex chiral architectures, either in a relay or sequential manner.

1 Introduction

2 NHC-Catalyzed Redox Reaction Combined with Aminocatalysis

3 NHC-Catalyzed Benzoin Condensation Combined with Aminocatalysis

4 NHC-Catalyzed Stetter reaction Combined with Aminocatalysis

5 Miscellaneous NHC Catalysis Combined with Aminocatalysis

6 Summary

Key words

organocatalysis - aminocatalysis - carbene catalysis - multiple catalytic reaction - cascade reaction

Volltext

Referenzen

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