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Synlett 2015; 26(19): 2720-2723
DOI: 10.1055/s-0035-1560491
DOI: 10.1055/s-0035-1560491
letter
Synthesis of New Alkylated Mononucleotide Analogues and Their Repair Proficiency by the Prokaryotic DNA Repair Protein AlkB
Further Information
Publication History
Received: 29 July 2015
Accepted after revision: 15 September 2015
Publication Date:
09 October 2015 (online)
Abstract
We describe the synthesis of a variety of new alkylated mononucleotides and examine their repair proficiency with the prokaryotic direct DNA repair protein AlkB. A comparison of rates of repair among the different substrates supports the currently accepted radical mechanism.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560491.
- Supporting Information
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References and Notes
- 1 Present address: Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.
- 2a Bernstein BE, Meissner A, Lander ES. Cell 2007; 128: 669
- 2b Schwartz S, Agarwala Sudeep D, Mumbach Maxwell R, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen Tarjei S, Satija R, Ruvkun G, Carr Steven A, Lander Eric S, Fink Gerald R, Regev A. Cell 2013; 155: 1409
- 3 Friedberg EC, Walker GC, Siede W, Wood RD. DNA Repair and Mutagenesis. American Society for Microbiology Press; Washington DC: 2005
- 4 Schärer OD. Angew. Chem. Int. Ed. 2003; 42: 2946
- 5a Mishina Y, Duguid E, He C. Chem. Rev. 2006; 106: 215
- 5b Zheng GQ, Fu Y, He C. Chem. Rev. 2014; 114: 4602
- 6 Delaney JC, Essigmann JM. Proc. Natl. Acad. Sci. U.S.A. 2004; 101: 14051
- 7 Li D, Fedeles BI, Shrivastav N, Delaney JC, Yang X, Wong C, Drennan CL, Essigmann JM. Chem. Res. Toxicol. 2013; 26: 1182
- 8 Maciejewska AM, Ruszel KP, Nieminuszczy J, Lewicka J, Sokołowska B, Grzesiuk E, Kuśmierek JT. Mutat. Res. 2010; 684: 24
- 9 Koivisto P, Duncan T, Lindahl T, Sedgwick B. J. Biol. Chem. 2003; 278: 44348
- 10 Trewick S, Henshaw T, Hausinger R, Lindahl T, Sedgwick B. Nature (London, U.K.) 2002; 419: 174
- 11 Duncan T, Trewick S, Koivisto P, Bates P, Lindahl T, Sedgwick B. Proc. Natl. Acad. Sci. U.S.A. 2002; 99: 16660
- 12 Ottria R, Casati S, Manzocchi A, Baldoli E, Mariotti M, Maier JA. M, Ciuffreda P. Bioorg. Med. Chem. 2010; 18: 4249
- 13 Jones JW, Robins RK. J. Am. Chem. Soc. 1963; 85: 193