(S)-Pyrrolidine-Containing Chiral Manganese(III)–Salalen and –Salan Complexes as Catalysts for the Asymmetric Henry Reaction

Abstract

Chiral Mn(III)–salalen and –salan complexes derived from (S)-proline have been used as catalysts for the asymmetric Henry (nitro-aldol) reaction. We have also used this methodology for a variety of substrates to afford nitroaldol products in 40–94% yields with 25–92% ee.

Key words

salalen complexes - nitro-aldol reaction - β-nitro-alcohol - asymmetric Henry reaction

• References and Notes

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