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Synthesis 2016; 48(03): 421-428
DOI: 10.1055/s-0035-1560967
DOI: 10.1055/s-0035-1560967
paper
Copper-Catalyzed O-Methylation of Carboxylic Acids Using DMSO as a Methyl Source
Weitere Informationen
Publikationsverlauf
Received: 18. September 2015
Accepted after revision: 27. Oktober 2015
Publikationsdatum:
19. November 2015 (online)


Abstract
A copper-catalyzed O-methylation of carboxylic acids using dimethyl sulfoxide (DMSO) as the methyl source is disclosed. This transformation exhibits a broad substrate scope and excellent functional group tolerance. Mechanistic studies indicate that a methyl radical is generated from dimethyl sulfoxide in the reaction process.
Key words
carboxylic acids - O-methylation - dimethyl sulfoxide - hydrogen peroxide - methyl radical - esterification - estersSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560967.
- Supporting Information