Three-Component Reaction for the Convenient Synthesis of Functionalized 3-{1-[2-(1H-Indol-3-yl)ethyl]-4,5,6,7-tetrahydro-1H-indol-3-yl}indolin-2-ones

Yan-Hong Jiang; Chao-Guo Yan

doi:10.1055/s-0035-1561457

Synthesis, Inhaltsverzeichnis

Synthesis 2016; 48(18): 3057-3064
DOI: 10.1055/s-0035-1561457

paper

Three-Component Reaction for the Convenient Synthesis of Functionalized 3-{1-[2-(1H-Indol-3-yl)ethyl]-4,5,6,7-tetrahydro-1H-indol-3-yl}indolin-2-ones

Yan-Hong Jiang

College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China eMail: cgyan@yzu.edu.cn

,

Chao-Guo Yan*

College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China eMail: cgyan@yzu.edu.cn

› Institutsangaben

Abstract

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Abstract

A simple synthetic protocol was developed for the efficient synthesis of functionalized 3-{1-[2-(1H-indol-3-yl)ethyl]-4,5,6,7-tetrahydro-1H-indol-3-yl}indolin-2-ones in high yield via three-component reaction of tryptamine, dimedone, and 3-phenacylideneoxindoles in refluxing acetonitrile with p-toluenesulfonic acid as catalyst.

Key words

multicomponent reaction - β-enaminone - tryptamine - isatin - dimedone - indole

Volltext

Referenzen

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17 CCDC 1407940 (1k) contains the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/structures.

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