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Synthesis 2016; 48(15): 2449-2454
DOI: 10.1055/s-0035-1561600
DOI: 10.1055/s-0035-1561600
paper
Synthesis of Cyclopropanated 7-Azabenzonorbornadienes
Further Information
Publication History
Received: 21 January 2016
Accepted after revision: 08 March 2016
Publication Date:
18 April 2016 (online)
Abstract
7-Azabenzonorbornadienes bearing various aryl or N-substituents were treated with diazomethane in the presence of palladium to afford desirable yields of cyclopropanated products (75–98%). The current approach suggests an efficient synthesis for CH2-cyclopropanated 7-azabenzonorbornadienes which lends promise to the development of new ring-opening preparations of biologically useful organic frameworks.
Key words
7-azabenzonorbornadiene - cyclopropanation - diazo compounds - diastereoselectivity - palladium catalysisSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561600.
- Supporting Information
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