Palladium-Catalyzed Nitration of Arenes by 1,2,3-Triazole-Directed C–H Activation

Abstract

An efficient palladium-catalyzed regioselective nitration of 1,4-disubstituted 1,2,3-triazoles has been described with good functional group compatibility, using Pd(OAc)₂ as the catalyst and NaNO₂ as the nitration source, leading to the synthesis of 1,2,3-triazoles containing nitro groups in good to excellent yields.

Key words

palladium - C–H activation - 1,4-disubstituted 1,2,3-triazoles - nitration - regioselectivity

• References

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