PDF herunterladen
Zeitschrift für Komplementärmedizin 2015; 07(04): 62-66
DOI: 10.1055/s-0035-1563690
zkm | Wissen
Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG Stuttgart

Vitamin D in der Krebsprävention

Die Vitamin-D-Zufuhr könnte mit dem Risiko für bestimmte Krebsarten zusammenhängen – Eine mögliche Evidenz besteht bislang nur für das kolorektale Karzinom
Tabea Böhler
,
Silya Nannen-Ottens
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
03. September 2015 (online)

    Lizenzen und Reprints

Zusammenfassung

Ein Zusammenhang zwischen Breitengrad und der Inzidenz von Krebserkrankungen wird schon länger vermutet. Verschiedene Studien haben eine mögliche Korrelation zwischen Vitamin-D-Versorgung und Krebsrisiko untersucht.

Die Autorinnen haben Studien zum kolorektalen Karzinom sowie zu Brust-, Prostata- und Pankreas-karzinom analysiert. Eine mögliche Evidenz lässt sich bisher lediglich beim kolorektalen Karzinom belegen.

Keywords

Vitamin D - Krebs - Krebsprävention - kolorektales Karzinom
 

  • Literatur

  • 1 Apperly FL.. The Relation of Solar Radiation to Cancer Mortality in North America. America. Cancer Res 1941; 92: 191-195
    Suche in Google Scholar
  • 2 Avenell A, MacLennan GS, Jenkinson DJ et al. Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D(3) and/or calcium (RECORD trial). J Clin Endocrinol Metab 2012; 97: 614-622
    CrossrefSuche in Google Scholar
  • 3 Bertone-Johnson ER, McTiernan A, Thomson CA et al. Vitamin D and calcium supplementation and one-year change in mammographic density in the women's health initiative calcium and vitamin D trial. Cancer Epidemiol Biomarkers Prev 2012; 21: 462-473
    CrossrefSuche in Google Scholar
  • 4 Bischoff-Ferrari HA.. Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes. Adv Exp Med Biol 2008; 624: 55-71
    Suche in Google Scholar
  • 5 Biesalski HK.. Vitamine. In: Bieaslki HK, Bischoff SC, Puchstein C, Hrsg. Ernährungsmedizin. 4. Aufl. Stuttgart: Thieme; 2010: 133-189
    Suche in Google Scholar
  • 6 Böcker W, Kreipe H.. Mamma. In: Böcker W, Denk H, Heitz PU et al., Hrsg. Pathologie. 5. Aufl. München: Elsevier, Urban & Fischer; 2012
    Suche in Google Scholar
  • 7 Bolland MJ, Grey A, Gamble GD et al. Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women's Health Initiative (WHI) limited-access data set. Am J Clin Nutr 2011; 94: 1144-1149
    CrossrefSuche in Google Scholar
  • 8 Brunner RL, Wactawski-Wende J, Caan BJ et al. The effect of calcium plus vitamin D on risk for invasive cancer: results of the Women's Health Initiative (WHI) calcium plus vitamin D randomized clinical trial. Nutr Cancer 2011; 63: 827-841
    CrossrefSuche in Google Scholar
  • 9 Chiang K-C, Chen TC.. The anti-cancer actions of vitamin D. Anti-Cancer Agents Med Chem Anti-Cancer Agents 2013; 13: 126-139
    Suche in Google Scholar
  • 10 Chlebowski RT, Johnson KC, Kooperberg C et al. Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst 2008; 100: 1581-1591
    CrossrefSuche in Google Scholar
  • 11 Ding EL, Mehta S, Fawzi WW et al. Interaction of estrogen therapy with calcium and vitamin D supplementation on colorectal cancer risk: reanalysis of Women's Health Initiative randomized trial. Int J Cancer 2007; 122: 1690-1694
    CrossrefSuche in Google Scholar
  • 12 DGE, Hrsg. New Reference Values for Vitamin D. Ann Nutr Metab 2012; 60: 241-246
  • 13 Feldman D, Krishnan AV, Swami S et al. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer 2014; 14: 342-357
    CrossrefSuche in Google Scholar
  • 14 Gallagher JC, Jindal PS, Smith LM.. Vitamin D supplementation in young White and African American women. J Bone Miner Res 2014; 29: 173-181
    CrossrefSuche in Google Scholar
  • 15 Gandini S, Boniol M, Haukka J et al. Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer 2011; 128: 1414-1424
    CrossrefSuche in Google Scholar
  • 16 Gilbert R, Martin RM, Beynon R et al. Associations of circulating and dietary vitamin D with prostate cancer risk: a systematic review and dose-response meta-analysis. Cancer Causes Control 2011; 22: 319-340
    CrossrefSuche in Google Scholar
  • 17 Grant WB.. Ecological studies of the UVB-vitamin D-cancer hypothesis. Anticancer Research 2012; 32: 223-236
    Suche in Google Scholar
  • 18 Holick MF.. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 2008; 19: 73-78
    Suche in Google Scholar
  • 19 Holick MF.. Vitamin D: its role in cancer prevention and treatment. Prog Biophys Mol Biol 2006; 92: 49-59
    CrossrefSuche in Google Scholar
  • 20 Lappe JM, Travers-Gustafson D, Davies KM et al. Vitamin D and calcium supplementation reduces cancer risk results of a randomized trial. Am J Clin Nutr 2007; 85: 1586-1591
    Suche in Google Scholar
  • 21 Lazzeroni M, Serrano D, Pilz S et al. Vitamin D supplementation and cancer review of randomized controlled trials. Anti-Cancer Agents in Medicinal Chemistry 2013; 13: 118-125
    CrossrefSuche in Google Scholar
  • 22 Lee JE, Li H, Chan AT et al. Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies. Cancer Prev Res 2011; 4: 735-743
    CrossrefSuche in Google Scholar
  • 23 Linseisen J, Bechthold A, Bischoff-Ferrari HA et al. Vitamin D und Prävention ausgewählter chronischer Krankheiten. Bonn: DGE; 2011
    Suche in Google Scholar
  • 24 Marshall DT, Savage SJ, Garrett-Mayer E et al. Vitamin D3 supplementation at 4000 international units per day for one year results in a decrease of positive cores at repeat biopsy in subjects with low-risk prostate cancer under active surveillance. J Clin Endocrinol Metab 2012; 97: 2315-2324
    CrossrefSuche in Google Scholar
  • 25 Mohr SB, Gorham ED, Alcaraz JE et al. Serum 25-hydroxyvitamin D and prevention of breast cancer pooled Analysis. Anticancer Research 2011; 31: 2939-2948
    Suche in Google Scholar
  • 26 Mohr SB, Gorham ED, Kim J et al. Meta-analysis of vitamin D sufficiency for improving survival of patients with breast cancer. Anticancer Research 2014; 34: 1163-1166
    Suche in Google Scholar
  • 27 Prentice RL, Pettinger MB, Jackson RD et al. Health risks and benefits from calcium and vitamin D supplementation: Women's Health Initiative clinical trial and cohort study. Osteoporos Int 2013; 24: 567-580
    CrossrefPubMedSuche in Google Scholar
  • 28 Ross AC, Taylor CL, Yaktine AL et al. Dietary Reference Intakes. Calcium. Vitamin D. Washington D.C.: 2011
    Suche in Google Scholar
  • 29 Tran B, Armstrong BK, Carlin JB et al. Recruitment and results of a pilot trial of vitamin D supplementation in the general population of Australia. J Clin Endocrinol Metab 2012; 97: 4473-4480
    CrossrefSuche in Google Scholar
  • 30 Trivedi DP, Doll R, Khaw KT.. Effect of four monthly oral vitamin D 3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003; 326: 469
    CrossrefSuche in Google Scholar
  • 31 Wactawski-Wende J, Kotchen JM, Anderson GL et al. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 2006; 354: 684-696
    CrossrefSuche in Google Scholar
  • 32 WHI Study Group. Design of the Women's Health Initiative clinical trial and observational study The Women's Health Initiative Study Group. Control Clin Trials 1998; 19: 61-109
  • 33 Xu Y, Shao X, Yao Y et al. Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk: new findings from an updated meta-analysis. J Cancer Res Clin Oncol 2014; 140: 1465-1477
    CrossrefSuche in Google Scholar
  • 34 Yin L, Grandi N, Raum E et al. Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Aliment Pharmacol Ther 2009; 30: 113-125
    CrossrefPubMedSuche in Google Scholar
  • 35 Yin L, Raum E, Haug U et al. Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk. Cancer Epidemiol 2009; 33: 435-445
    CrossrefSuche in Google Scholar
  • 36 Yin L, Grandi N, Raum E et al. Meta-analysis: serum vitamin D and breast cancer risk. Eur J Cancer 2010; 46: 2196-2205
    CrossrefSuche in Google Scholar