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Pharmacopsychiatry 2016; 49(02): 51-56
DOI: 10.1055/s-0035-1569267
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Association Study of 60 Candidate Genes with Antipsychotic-induced Weight Gain in Schizophrenia Patients

S. Ryu
1   Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
,
I.-S. Huh
2   Department of Statistics, Seoul National University, Seoul, Korea
,
E.-Y. Cho
3   Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Korea
,
Y. Cho
1   Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
,
T. Park
2   Department of Statistics, Seoul National University, Seoul, Korea
,
S. C. Yoon
1   Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
,
Y. H. Joo
4   Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
,
K. S. Hong
1   Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
2   Department of Statistics, Seoul National University, Seoul, Korea
› Author Affiliations
Further Information

Publication History

received 13 January 2015
revised 04 October 2015

accepted 11 November 2015

Publication Date:
04 February 2016 (online)

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Abstract

Introduction: This study aimed to investigate the association of multiple candidate genes with weight gain and appetite change during antipsychotic treatment.

Methods: A total of 233 single nucleotide polymorphisms (SNPs) within 60 candidate genes were genotyped. BMI changes for up to 8 weeks in 84 schizophrenia patients receiving antipsychotic medication were analyzed using a linear mixed model. In addition, we assessed appetite change during antipsychotic treatment in a different group of 46 schizophrenia patients using the Drug-Related Eating Behavior Questionnaire.

Results: No SNP showed a statistically significant association with BMI or appetite change after correction for multiple testing. We observed trends of association (P<0.05) between 19 SNPs of 11 genes and weight gain, and between 7 SNPs of 5 genes and appetite change. In particular, rs696217 in GHRL showed suggestive evidence of association with not only weight gain (P=0.001) but also appetite change (P=0.042). Patients carrying the GG genotype of rs696217 exhibited higher increase in both BMI and appetite compared to patients carrying the GT/TT genotype.

Discussion: Our findings suggested the involvement of a GHRL polymorphism in weight gain, which was specifically mediated by appetite change, during antipsychotic treatment in schizophrenia patients.

Key words

pharmacogenetics - schizophrenia - antipsychotic-induced weight gain - appetite - GHRL

Supporting Information

 

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