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Pharmacopsychiatry 2016; 49(02): 76-78
DOI: 10.1055/s-0035-1569268
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

A Case Report of a Carbamazepine Overdose With Focus on Pharmacokinetic Aspects

N. Mittag
1   Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany
,
S. Meister
2   Department of Neurology, University of Rostock, Rostock, Germany
,
A. M. J. Berg
1   Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany
,
U. I. Walther
1   Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany
› Author Affiliations
Further Information

Publication History

received 17 September 2015
revised 17 September 2015

accepted 11 November 2015

Publication Date:
21 January 2016 (online)

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Abstract

In this article a case of carbamazepine overdose is reported. It is common to use immuno-based methods in the field of therapeutic drug monitoring but it might be difficult to adapt such values to toxicological cases. For carbamazepine overdoses it is recommended also to determine the metabolite carbamazepine-10,11-epoxide. Especially for critical conditions a definite substance identification should be performed. In addition, quantifying main metabolites is recommended for an acute clinical toxicological assessment.

Key words

therapeutic drug monitoring - toxicological assessment
 

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