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Semin Thromb Hemost 2016; 42(03): 234-241
DOI: 10.1055/s-0036-1571308
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Platelets and Antiplatelet Therapy in Patients with Coronary Artery Disease and Diabetes

Søs Neergaard-Petersen
1   Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
,
Anne-Mette Hvas
2   Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
,
Steen Dalby Kristensen
1   Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
,
Erik Lerkevang Grove
1   Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
› Author Affiliations
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Publication History

Publication Date:
17 February 2016 (online)

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Abstract

Patients with diabetes mellitus are at increased risk of cardiovascular events. Despite advances in medical and interventional therapy, cardiovascular morbidity and mortality remains high in patients with diabetes. Although accelerated atherosclerosis has long been recognized as an underlying cause, recent studies suggest that changes in platelets and coagulation also play important roles. Patients with diabetes exhibit a prothrombotic milieu with hyperreactive platelets and coagulation abnormalities. Thus, prevention of cardiovascular events in patients with coronary artery disease (CAD) and diabetes involves a multifactorial approach including treatment of risk factors such as dyslipidemia, obesity, hypertension, hyperglycemia, and hypercoagulation. An impaired response to antiplatelet therapy has been consistently reported and optimization of this therapy seems appropriate to reduce the risk of cardiovascular events in these patients. In this review, platelet abnormalities are summarized together with an update of benefits and limitations of antiplatelet therapy in patients with CAD and diabetes.

Keywords

ADP receptor blockers - aspirin - coronary artery disease - diabetes mellitus - platelet aggregation - platelets
 

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