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Neuropediatrics 2016; 47(03): 175-178
DOI: 10.1055/s-0036-1578797
DOI: 10.1055/s-0036-1578797
Short Communication
Plasma Exchange and Immunoadsorption in Pediatric Inflammatory Optic Neuropathy Resistant to Corticosteroid Therapy: Four French Cases
Further Information
Publication History
25 September 2015
11 January 2016
Publication Date:
29 February 2016 (online)
Abstract
Steroids as a foremost therapy are widely used in pediatric optic neuritis (ON). Yet, this treatment is not standardized to date. Some children show a resistance to the classic treatment by steroids. Although plasma exchange (PE) and immunoadsorption (IA) techniques are increasingly being adopted and lead to good results in resistant cases in adult patients, very few studies have shown interest in treating ON when steroids have failed. In this study, we report four observations of children, two of whom are treated by PE and two by IA techniques, describing the treatment protocols together with the side effects observed.
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References
- 1 Roed H, Frederiksen J, Langkilde A, Sørensen TL, Lauritzen M, Sellebjerg F. Systemic T-cell activation in acute clinically isolated optic neuritis. J Neuroimmunol 2005; 162 (1–2) 165-172
- 2 Martinez-Hernandez E, Sepulveda M, Rostásy K , et al. Antibodies to aquaporin 4, myelin-oligodendrocyte glycoprotein, and the glycine receptor α1 subunit in patients with isolated optic neuritis. JAMA Neurol 2015; 72 (2) 187-193
- 3 Cole SR, Beck RW, Moke PS, Gal RL, Long DT. The National Eye Institute Visual Function Questionnaire: experience of the ONTT. Optic Neuritis Treatment Trial. Invest Ophthalmol Vis Sci 2000; 41 (5) 1017-1021
- 4 Lucchinetti CF, Kiers L, O'Duffy A , et al. Risk factors for developing multiple sclerosis after childhood optic neuritis. Neurology 1997; 49 (5) 1413-1418
- 5 Pula JH, Macdonald CJ. Current options for the treatment of optic neuritis. Clin Ophthalmol 2012; 6: 1211-1223
- 6 Beck RW, Cleary PA, Anderson Jr MM , et al; The Optic Neuritis Study Group. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. N Engl J Med 1992; 326 (9) 581-588
- 7 Weinshenker BG, O'Brien PC, Petterson TM , et al. A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease. Ann Neurol 1999; 46 (6) 878-886
- 8 Ruprecht K, Klinker E, Dintelmann T, Rieckmann P, Gold R. Plasma exchange for severe optic neuritis: treatment of 10 patients. Neurology 2004; 63 (6) 1081-1083
- 9 Roesner S, Appel R, Gbadamosi J, Martin R, Heesen C. Treatment of steroid-unresponsive optic neuritis with plasma exchange. Acta Neurol Scand 2012; 126 (2) 103-108
- 10 Michaelis I, Bender B, Beringer O, Melms A, Krägeloh-Mann I, Wolff M. Plasma exchange is effective in a 13-year-old girl with steroid-resistant bilateral optic neuritis. Neuropediatrics 2013; 44 (5) 272-275
- 11 Baumer FM, Kamihara J, Gorman MP. Neuromyelitis optica in an adolescent after bone marrow transplantation. Pediatr Neurol 2015; 52 (1) 119-124
- 12 Koziolek M, Mühlhausen J, Friede T , et al. Therapeutic apheresis in pediatric patients with acute CNS inflammatory demyelinating disease. Blood Purif 2013; 36 (2) 92-97
- 13 Koziolek MJ, Tampe D, Bähr M , et al. Immunoadsorption therapy in patients with multiple sclerosis with steroid-refractory optical neuritis. J Neuroinflammation 2012; 9: 80
- 14 Klingel R, Heibges A, Fassbender C. Neurologic diseases of the central nervous system with pathophysiologically relevant autoantibodies—perspectives for immunoadsorption. Atheroscler Suppl 2013; 14 (1) 161-165