Keywords
Rosenmuller fossa - skull base - anterior - case report - endoscopic - nasal septal
flap - endonasal - pharyngeal recess
Introduction
Penetrating trauma of the skull base can occur by any number of mechanisms, but often
involves the use of firearms. Fractures at the anterior base of the skull are common
in these injuries,[1] and often result in cerebrospinal fluid (CSF) leaks. The gold standard for diagnosing
CSF leak is the β-2 transferrin test. However, the “halo sign” has also traditionally
been used. CSF leaks may be either spontaneous or traumatic, and most traumatic CSF
leaks will resolve within 1 week.[2] In contrast, CSF leak with delayed occurrence has a low likelihood of resolving
without surgery.[3]
The fossa of Rosenmuller is also known as the posterolateral recess or the pharyngeal
recess. It is formed by nasal sinus mucosal reflections over the longus colli muscle
and is located posterior and superior to the ostium of the Eustachian tube.[4]
[5]
Here, we present the unusual case of delayed-onset, traumatic CSF leak in a young
man with a bullet fragment lodged in the fossa of Rosenmuller who underwent nasal
endoscopic repair.
History and Examination
A 21-year-old man presented with rhinorrhea 6 weeks after sustaining a gunshot wound
to the face entering through the maxilla. Initially following the injury, he was diagnosed
with a fractured mandible, fractured right occipital condyle, and right orbital floor
blowout by computed tomography imaging. A retained ballistic fragment located near
the left occipital condyle was also identified. A CSF leak was not present during
the first hospitalization, and angiographic studies did not reveal arterial injury.
Due to the location of the retained fragment and the lack of a CSF leak, the patient
was managed conservatively. He was discharged home after further observation. After
6 weeks, the patient presented with rhinorrhea. Imaging at that time revealed the
path of the bullet through the right maxilla, the right maxillary sinus traversing
the nasopharynx, with the projectile coming to rest just left of the clivus in the
pharyngeal recess (fossa of Rosenmuller), as shown in [Fig. 1]. Due to the delayed presentation and abundant CSF rhinorrhea, further observation
or lumbar drain placement were thought to be inadequate. It was felt the CSF leak
was likely coming from the skull base near the site of the retained fragment. Nasal
endoscopic surgery for exploration and identification of the dural defect was sought.
Fig. 1 Computed tomography with angiography demonstrating trajectory of the missile. (A) Coronal image showing the path of the bullet through the maxilary sinus on the right
side with residual osseous fragments. (B) Coronal image depicting the bullet resting just left of the clivus in Rosenmuller
fossa. Note proximity to the internal carotid artery to Rosenmuller fossa. (C) Axial image at the level of C1, just superior to the bifurcation of the common carotid
artery. The internal carotid artery, external carotid artery, and internal jugular
vein are appreciated lateral to the bullet.
Operation and Postoperative Course
Operation and Postoperative Course
A uninostril endonasal approach was performed, including a posterior septectomy, left
ethmoidectomy and maxillectomy. A nasoseptal flap was obtained for the repair. The
midline heel of the hard palate was drilled to increase the inferior view. After exposing
the left pterygoid plate, the scar tissue of pharyngobasilar fascia was divided to
expose the Eustachian tube and lower clivus. The Eustachian tube was mobilized laterally
and inferiorly, exposing the bullet fragment ([Fig. 2A]). After further dissection and subsequent bullet extraction, a vertical linear defect
along the lateral aspect of the clivus down to Rosenmuller fossa was identified ([Fig. 2B]). A multilayered repair consisting of a dural substitute, fibrin glue, and the nasoseptal
flap was performed. A lumbar drain was not inserted.
Fig. 2 Endoscopic view. (A) Intraoperative endoscopic view of retained ballistic fragment located within the
left fossa of Rosenmuller. The bilateral Eustachian tubes are visualized. Traumatic
changes are noted in the nasopharynx and the patient's left Eustachian tube which
is displaced laterally by the suction tip. The soft palate is labeled for reference.
(B) Intraoperative endoscopic view of dural defect after resection of necrotic tissue
and extraction of the ballistic fragment. Cerebrospinal fluid was noted to egress
from the dural defect. ET, Eustachian tube; NP, nasopharynx.
Nasal packing was placed postoperatively and was removed 7 days after surgery. CSF
leak was not present immediately postoperatively. There were no postoperative complications,
and the patient was discharged on postoperative day 2. As of 3-month follow-up, the
patient's CSF leak has not returned.
Discussion
To our knowledge, our case is the first report of a missile becoming lodged within
Rosenmuller fossa, resulting in delayed CSF leak. Operating in this space requires
consideration for the position of the internal carotid artery, which is usually situated
laterally to the Rosenmuller fossa. There is limited information available on treating
this type of injury. A previous case report reviews a delayed traumatic CSF leak from
Rosenmuller fossa in a 3-year-old child after a fall. She was found to have a CSF
fistula originating from the medial part of the sphenoid, which was repaired successfully
with a fascia lata graft at the anterior skull base.[6] A second, more recent report describes a 57-year-old woman with a bullet lodged
within the sphenoid bone who was found to have CSF leak at initial presentation.[7] The bullet was removed transnasally with endoscopic surgery, and she had no evidence
of CSF leak at 6 months follow-up.
While CSF leak following trauma or surgery is far more common than spontaneous CSF
leak, it remains relatively rare. Rates of CSF leak following any head trauma have
been reported at 2 to 3%.[2] In a study of 1,278 patients with maxillofacial trauma, 17 (1.3%) had CSF leak.[8] All of these patients had skull-base fractures. However, rates of CSF leak are likely
higher for patients suffering from missile wounds. In one study from the Vietnam War,
of 1,133 men with missile wounds of the brain, 101 (8.9%) were complicated by CSF
fistula.[9] Current data are lacking regarding the incidence of delayed traumatic CSF leak.
Skull-base CSF leaks are usually repaired with endonasal surgery, and nasoseptal flap(s)
are often implemented. Patients treated in this fashion have been shown to have less
morbidity.[10] Other authors have commented on the reliability of the nasoseptal flap to cover
a range of skull-base defects as well as its ease of harvesting, making it first-line
treatment in such scenarios.[11] Dual and triple flap techniques that combine various anterior, lateral, and nasoseptal
flaps can also be used in extensive and severe cases.[12]
Recent studies aimed at understanding CSF leaks originating at the skull base have
focused on risks for recurrence postoperatively. Size of dural defect and location
of surgery have been found to be important risk factors for CSF leak in skull-base
reconstruction using nasoseptal flaps, with dural defects larger than 2.0 cm2 and surgery to the sella or clivus posing a greater risk.[13] Despite a heightened risk for postoperative recurrence, the patient's CSF leak had
not returned 3 months postoperatively following the multilayered repair.
In conclusion, we present a case of foreign body penetration into Rosenmuller fossa
treated successfully with nasal endoscopic surgical repair.
