Synlett 2017; 28(11): 1368-1372
DOI: 10.1055/s-0036-1588158
letter
© Georg Thieme Verlag Stuttgart · New York

Copper Triflate Catalyzed Oxidative α-Allylation of Glycine Derivatives

Ting-Ting Chen
College of Chemical Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei, Nanjing, 210094, P. R. of China   Email: c.cai@njust.edu.cn
,
Chun Cai*
College of Chemical Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei, Nanjing, 210094, P. R. of China   Email: c.cai@njust.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 07 January 2017

Accepted after revision: 26 February 2017

Publication Date:
15 March 2017 (online)


Abstract

Copper triflate catalyzed oxidative C–H functionalization of glycine derivatives with allyltributyltin has been established using oxygen or tert-butyl hydroperoxide as oxidant. Various glycine esters and glycine amides were suitable substrates for this oxidative allylation reaction and afforded the desired homoallylic amines in moderate to good yields.

Supporting Information