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Synthesis 2017; 49(18): 4321-4326
DOI: 10.1055/s-0036-1588181
DOI: 10.1055/s-0036-1588181
paper
Sc(OTf)3-Catalyzed Oligomerization of Indole: One-Pot Synthesis of 2-[2,2-Bis(indol-3-yl)ethyl]anilines and 3-(Indolin-2-yl)indoles
The authors are grateful to Council of Scientific and Industrial Research (CSIR), New Delhi for financial support [01(2214)/08/EMR-II] and GMS thanks CSIR for the award of a senior research fellowship.Weitere Informationen
Publikationsverlauf
Received: 11. Mai 2017
Accepted after revision: 12. Mai 2017
Publikationsdatum:
01. August 2017 (online)


Abstract
Oligomerization of substituted indoles and N-methylindoles was investigated in the presence of catalytic amounts of scandium triflate in dichloromethane. Two types of indole oligomer, 2-[2,2-bis(indol-3-yl)ethyl]anilines and 3-(indolin-2-yl)indoles were obtained based on the substituent on indole ring. This study constitutes the first example of Sc(OTf)3-catalyzed oligomerization of indoles and gave good yield of 2-[2,2-bis(indol-3-yl)ethyl]anilines and 3-(indolin-2-yl)indoles.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588181.
- Supporting Information