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Synthesis 2017; 49(02): 293-298
DOI: 10.1055/s-0036-1588349
DOI: 10.1055/s-0036-1588349
paper
N-Heterocyclic Carbene and Chiral Brønsted Acid Cooperative Catalysis for a Highly Enantioselective [4+2] Annulation
Further Information
Publication History
Received: 14 October 2016
Accepted: 20 October 2016
Publication Date:
18 November 2016 (online)
![](https://www.thieme-connect.de/media/synthesis/201702/lookinside/thumbnails/ss-2016-z0726-op_10-1055_s-0036-1588349-1.jpg)
Dedicated to Professor Dieter Enders, a pioneer in NHC catalysis, on the occasion of his 70th birthday.
Abstract
A chiral NHC/Brønsted acid cooperative catalysis system has been developed for the asymmetric annulation of functionalized benzaldehydes and activated ketones, through dearomative generation of dienolate, to give 3-aryl-3-(perfluoroalkyl)isochroman-1-ones.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588349.
- Supporting Information
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