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Synlett 2017; 28(16): 2131-2134
DOI: 10.1055/s-0036-1588478
DOI: 10.1055/s-0036-1588478
letter
Fluoropyridyl Sugars – Masked Imidate Glycosyl Donors that Display Reactivity, Selectivity, and Stability
Further Information
Publication History
Received: 01 June 2017
Accepted: 01 June 2017
Publication Date:
11 July 2017 (online)
![](https://www.thieme-connect.de/media/synlett/201716/lookinside/thumbnails/st-2017-d0419-l_10-1055_s-0036-1588478-1.jpg)
Abstract
Fluoropyridyl glycosides, synthesized from the corresponding glycosyl bromides, are shown to be excellent donors in glycosylation reactions. Both armed and disarmed donors were prepared and reacted smoothly with a series of glycosyl acceptors. Coupling proceeded in high yields, with activation of the donor achieved using a range of promoters, and also displayed unusually high selectivity. In addition these novel systems offer the potential for introducing a series of glycosyl donors with ‘tunable reactivity’.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588478.
- Supporting Information
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References and Notes
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