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Synthesis 2017; 49(19): 4517-4522
DOI: 10.1055/s-0036-1588498
DOI: 10.1055/s-0036-1588498
paper
Convenient Synthesis of Oxazolo[5,4-h]pyrrolo[4,3,2-de]quinolones via Hypervalent Iodine Mediated Intramolecular Oxidative Cyclization
We are grateful for the funds supported by the National Natural Science Foundation (No. 21472243), the Qing Lan Project in Jiangsu Province, and the National College Students Innovation Training Program.Further Information
Publication History
Received: 20 March 2017
Accepted after revision: 16 June 2017
Publication Date:
19 July 2017 (online)
Abstract
A convenient and practical method has been developed for the synthesis of substituted oxazolo[5,4-h]pyrrolo[4,3,2-de]quinolones via the intramolecular oxidative cyclization by using PIFA as oxidant and TMSOTf as additive in DCE under an air atmosphere. The reaction proceeds in good yields and has good functional groups tolerance.
Key words
intramolecular - PIFA - oxidative cyclization - C–O formation - pyrrolo[4,3,2-de]quinoloneSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588498.
- Supporting Information
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