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Synthesis 2018; 50(02): 330-340
DOI: 10.1055/s-0036-1588576
DOI: 10.1055/s-0036-1588576
paper
Palladium-Catalyzed One-Pot Synthesis of N-Sulfonyl, N-Phosphoryl, and N-Acyl Guanidines
This project is supported by the National Natural Science Foundation of China (No. 21672256), the National S&T Pillar Program of China (2015BAK45B01), and Chinese Universities Scientific Fund (2017QC152).Further Information
Publication History
Received: 06 July 2017
Accepted after revision: 31 August 2017
Publication Date:
12 October 2017 (online)
Abstract
An efficient palladium-catalyzed cascade reaction of azides with isonitrile and amines is presented; it offers an alternative facile approach toward N-sulfonyl-, N-phosphoryl-, and N-acyl-functionalized guanidines in excellent yield. These series of substituted guanidines exhibit potential biological and pharmacological activities. In addition, the less reactive intermediate benzoyl carbodiimide could be isolated by silica gel column flash chromatography in moderate yield.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588576.
- Supporting Information
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