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Synthesis 2017; 49(02): 260-268
DOI: 10.1055/s-0036-1588609
DOI: 10.1055/s-0036-1588609
paper
Sodium Chloride Catalyzed Regioselective Trifluoromethylthiolation of Furans
Further Information
Publication History
Received: 20 July 2016
Accepted after revision: 05 September 2016
Publication Date:
13 October 2016 (online)
![](https://www.thieme-connect.de/media/synthesis/201702/lookinside/thumbnails/ss-2016-t0511-op_10-1055_s-0036-1588609-1.jpg)
Dedicated to Prof. Dieter Enders on the occasion of his 70th birthday
Abstract
Here, we report the catalytic trifluoromethylthiolation of furans employing sodium chloride as an inexpensive, abundant and ecologically friendly catalyst. The developed method exhibits perfect regioselectivity and a high functional group tolerance. Furthermore, the robustness of the newly developed method was determined by the additive-based Robustness Screen.
Key words
trifluoromethylthiolation - sodium chloride - bioactive compounds - heterocycles - synthetic methodsSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588609.
- Supporting Information
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For recent reviews on electrophilic trifluoromethylthiolation, see:
For the development of electrophilic trifluoromethylthiolation reagents, see:
For examples of C–H functionalizations of heteroarenes using reagents 1–5, see:
For other methodologies for synthesizing trifluoromethylthiolated furans, see:
For information about the Robustness Screen, see: