Pd(OAc)₂-Catalyzed Desulfinative Cross-Coupling of Sodium Sulfinates with β-Bromostyrenes: Synthesis of Tamoxifen

Abstract

A Pd(OAc)₂-catalyzed desulfinative cross-coupling of (Z)-β-halostyrenes with sodium sulfinates in the presence of PPh₃ and Na₂CO₃ at reflux in good yields is reported. The stereocontrolled cross-coupling process provides a series of sulfonylmethyl (Z)-stilbenes. A synthesis of tamoxifen was studied.

Key words

desulfinative cross coupling - halostyrenes - sodium sulfinates - stilbenes - tamoxifen

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