Synthesis of N-Sulfonyl Ynamido-Phosphonates: Valuable Partners for Cycloadditions

Abstract

N-Sulfonyl ynamido-phosphonates were prepared from sulfonamides and bromo alkynylphosphonates through a direct copper-catalyzed coupling reaction. The substrates were obtained in good to excellent yields. The latter are valuable partners to react with nitrile-oxides­ to form isoxazoles in good yields and with an exclusive regio­selectivity.

Key words

ynamides - phosphonates - copper catalysis - cycloadditions - isoxazoles

• References

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